EGFR与DEC1蛋白共表达促进肺腺癌肿瘤细胞淋巴结转移  

GFR and DEC1 protein co-expression promotes lymph node metastasis in lung adenocarcinoma

作　　者：马育华[1,2] 郑燕[3] 郏雁飞[3] 汪运山[3] 

机构地区：[1]山东大学医学院,济南250012 [2]临沂市人民医院检验科,山东临沂276003 [3]山东大学附属济南市中心医院中心实验室,济南250013

出　　处：《山东大学学报（医学版）》2012年第3期24-28,共5页Journal of Shandong University:Health Sciences

基　　金：国家自然科学基金资助项目(81000869);山东省优秀中青年科学家科研奖励基金资助项目(BS2011YY039);济南"泉城学者"建设工程招标课题(Q2-06)

摘　　要：目的探讨EGFR和DEC1在肺腺癌中的表达及与临床特征的关系。方法采用免疫组织化学方法检测75例肺腺癌癌组织及癌旁组织EGFR和DEC1的表达。结果在癌组织中,EGFR胞膜上的表达为45.3%(34/75),DEC1胞核上的表达为54.7%(41/75),两者均与癌旁组织的表达有统计学差异(P<0.001);EGFR的表达与组织分化(P=0.033)、淋巴结转移(P=0.006)和远处转移(P=0.043)相关,DEC1与年龄(P=0.026)和肿瘤大小(P=0.047)相关。表达模式为EGFR+/DEC1+的肺腺癌患者比EGFR-/DEC1-的患者发生淋巴结转移的百分率高,两者有统计学差异(P=0.024)。结论 EGFR和DEC1蛋白的共表达可促进肺腺癌患者淋巴结转移。Objective To investigate the association of expressions of epidermal growth factor receptor（EGFR） and differentiated embryo-chondrocyte expressed gene 1（DEC1） in lung adenocarcinoma to its clinicopathological characteristics.Methods Expressions of EGFR and DEC1 in 75 cases of lung adenocarcinoma were detected by immnohistochemistry.Results The positive membrane expression rates of EGFR and nuclear DEC1 in lung adenocarcinoma tissues were 45.3%（34/75）and 54.7%（41/75）respectively,which were significantly higher than those in adjacent normal tissues（P0.001）.Expression of membrane EGFR in lung adenocarcinoma was related to tissue histological differentiation（P=0.033）,lymph node metastasis（P=0.006） and distant metastasis（P=0.043）.Expression of nuclear DEC1 in lung adenocarcinoma was associated with patients′ age（P=0.026） and tumor size（P=0.047）.Co-expression of EGFR and DEC1 in lung adenocarcinoma was related to lymph node metastasis（P=0.024）.Conclusion The interaction of EGFR and DEC1 promotes lymph node metastasis in lung adenocarcinoma.

关 键 词：肺腺癌 表皮生长因子受体 分化型胚胎软骨细胞表达基因1 淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤]