盐酸氮卓斯汀滴眼液治疗儿童变态反应性结膜炎的疗效  

Clinical study of Azelastine eye drops in children with allergic conjunctivitis

作　　者：贾惠莉[1] 刘春民[1] 邓宏伟[1] 韩冰[1] 朱小丽[1] 

机构地区：[1]中国广东省深圳市眼科医院小儿眼科,518018

出　　处：《国际眼科杂志》2012年第4期780-781,共2页International Eye Science

摘　　要：目的:观察氮卓斯汀滴眼液治疗儿童变态反应性结膜炎的临床疗效。方法:变态反应性结膜炎患儿30例随机分为两组:对照组单用玻璃酸钠滴眼液,试验组联合应用玻璃酸钠滴眼液与0.5g/L盐酸氮卓斯汀滴眼液,治疗前后观察眨眼、眼痒症状、结膜水肿、结膜充血及上、下睑结膜乳头和滤泡、角膜缘腺样增生等体征,评价治疗有效率。结果:对照组症状、体征评分治疗前后分别为4.60±0.87,4.72±1.53与2.53±1.45,2.40±1.20;试验组症状、体征评分治疗前后分别为4.72±0.77,5.29±1.46与1.47±1.48,1.59±1.12,两组差异有统计学意义(P<0.05)。对照组与试验组治疗后有效率分别为33%和73%,差异有统计学意义(P<0.05)。结论:盐酸氮卓斯汀滴眼液是一种有效而安全的治疗儿童变态反应性结膜炎的药物。AIM：To evaluate the treatment of Azelastine eye drops in children with allergic conjunctivitis.METHODS：Thirty children patients（60 eyes） with allergic conjunctivitis were enrolled.A randomnized and controlled study was adopted including the control group and the test group.Symptoms and signs were evaluated before and after treatment.The control group used Hyaluronate eye drops and the test group was treated with Hyaluronate plus 0.05% Azelastine eye drops.RESULTS：The respective scores of all symptoms and signs in the control group were 4.60±0.87,4.72±1.53 and 2.53±1.45,2.40±1.20 before and after treatment,4.72±0.77,5.29±1.46 and 1.47±1.48,1.59±1.12 for the test group.The effective rates in the control and test groups were 33% and 73%.There was significant difference between the control and test groups.CONCLUSION：Azelastine eye drops is effective and safe in the treatment of children patients with allergic conjunctivitis.

关 键 词：盐酸氮卓斯汀 变态反应性结膜炎 儿童 

分 类 号：R777.31[医药卫生—眼科]