微血管周细胞在缺血性脑损伤中的作用  

Roles of Brain Pericytes in Cerebral Ischemic Injury

作　　者：陈继兴[1] 钱加强[1] 

机构地区：[1]福建医科大学第二临床医学院,福建泉州362000

出　　处：《中国医学创新》2012年第9期152-156,共5页Medical Innovation of China

摘　　要：近年来,周细胞在脑组织中的存在和作用越来越受到关注。作为微血管的构成成分之一,大脑周细胞参与调节多种功能,如微循环的灌流量和通透性、血脑屏障的完整性、脑损伤后血管生成和重建等。最近的研究也表明,它们在某种程度上类似于间充质干细胞。正因为大脑周细胞积极参与并调节这些功能,因此在脑缺血急性期及后期,这些细胞可能起着重要的作用。The existence and effect of pericytes have been paid more attention in recent years. As one of the components of microvessels, brain pericytes regulate a variety of functions, such as the perfusion and permeability of microcirculation, the integrity of the blood-brain barrier and the angiogenesis after cerebral injury. Recent studies have also shown that they have stem cell potential. Since, brain pericytes actively control these functions, these cells probably play an important role not only during brain ischemia, but also in the post-stroke period.

关 键 词：周细胞 脑缺血 血管生成 神经再生 血脑屏障 

分 类 号：R743[医药卫生—神经病学与精神病学]