阿司匹林缓释片不同骨架材料缓释效果的探讨  

Aspirin Sustained Release Tablets of Different Slow-release Effect of Skeleton Material

作　　者：张晓旭[1] 陈敏余[1] 陈梓华[1] 邢婧[1] 余奕[1] 陈晓娜[1] 

机构地区：[1]中山大学药学院,广州510006

出　　处：《北方药学》2012年第3期33-34,共2页Journal of North Pharmacy

摘　　要：为了降低阿司匹林的胃黏膜刺激性,延长其作用时间,本研究设计了阿司匹林缓释片剂。通过采用不同的骨架材料设计了三个试验处方和一个空白对照处方,并对各处方制得的片剂进行溶出释放度的检查,探讨不同骨架材料制备得到的阿司匹林片剂的缓释效果。结果证明本试验的缓释处方制得的片剂均有缓释作用,且EC比HPMC的缓释效果更强一些,HPMC、EC混合骨架材料缓释效果最强,但存在溶出太慢问题。To decrease the gastric mucosa irritation of Aspirin, and extend its time of action, The present study designed Aspirin sustained-release tablet. We designed three experimental formulas and a blank control one, and did the dissolution tests, to discuss the sustained-release effect of different tablets. The results prove that the sustained-release tablets made according to the experimental formulas take sustained-release effect, Tablets with EC have better sustained-release effect than HPMC. Those with both HPMC and EC dissolve most slowly, but there are some dissolution problems.

关 键 词：阿司匹林缓释片 骨架材料 HPMC EC 溶出度 

分 类 号：R944[医药卫生—药剂学]