肿瘤标志物(TM)在临床中的应用  

Application of tumor marker(TM) in clinic

作　　者：赵士艳(综述)[1] 刘兴党[2] 管樑[3] 聂秀利[1] 严惟力(审校)[1] 

机构地区：[1]上海交通大学医学院附属仁济医院核医学科,上海200127 [2]复旦大学附属华山医院核医学科,上海200040 [3]上海交通大学医学院附属瑞金医院核医学科,上海200025

出　　处：《复旦学报（医学版）》2012年第2期194-197,共4页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金(30770599);上海教委科技创新项目(09YZ82)~~

摘　　要：恶性肿瘤的早期诊断是有效治疗癌症的关键。肿瘤标志物(tumor marker,TM)对于原发肿瘤的早期诊断具有重要的意义,同时还能预测疗效和预后。随着细胞生物学和分子生物学的发展,TM及其应用已成为临床研究肿瘤早期诊断的热点。目前临床使用的TM的敏感性和特异性尚不能达到理想状态,合理选择几种TM进行联检可以提高检测的敏感性和特异性。本文主要对几种临床上常用的TM和近期发现的有重要应用前景的TM作一综述。Early detection of malignancy is the key to effective treatment of cancer. Tumor marker （TM） could be useful for early diagnostics of primary tumors and relapsed disease, as well as for predicting therapeutic effect and prognosis. With the recent advances in cellular and molecular biology, TM and its application have become hot spot of clinical research in early diagnosis for tumor. Although the sensitivity and specificity of any common TM are not satisfactory, it＇s better to combine several kinds of TMs. This paper summarizes the common-use TMs in clinical diagnosis and the newly- discovered potential TMs.

关 键 词：肿瘤标志物(TM) 肺癌 原发性肝细胞癌 乳腺癌 胰腺癌 

分 类 号：R730.4[医药卫生—肿瘤]