胃食管反流食管外症状的治疗研究  

Treatment of Extraesophageal Sympotoms in Patients with Gastroesophageal Reflux

作　　者：金忠海[1] 楼放毅[1] 楼正才[2] 吴小洪[2] 陈华英[2] 应光荣[1] 

机构地区：[1]浙江省义乌市中心医院消化内科,322000 [2]浙江省义乌市中心医院耳鼻喉科

出　　处：《医学研究杂志》2012年第3期68-70,共3页Journal of Medical Research

基　　金：2010年义乌市科技基金资助项目

摘　　要：目的探讨胃食管反流食管外症状的诊断及治疗。方法 218例伴食管外症状的GERD患者随机分为3组,给予莫沙必利+奥美拉唑20mg每日1次(A组)、奥美拉唑20mg每日1次(B组)及莫沙必利+奥美拉唑20mg每日1次(C组)治疗。观察治疗6个月的症状及体征情况。结果 B组与A、C两组症状有效率及痊愈率差异显著(P<0.05);然而,A组与C组无显著差异(P>0.05),但C组显示比A组高18%的痊愈率。此外,B组与A、C两组体征有效率无显著差异(P>0.05)。但C组与A、B两组痊愈率差异显著(P<0.05)。结论双倍剂量质子泵抑制剂+莫沙必利可有效控制胃食管反流食管外症状。Objective To discuss the diagnosis and treatment of extraesophageal sympotoms in patients with gastroesophageal reflux. Methods A total of 218 patients with extraesophageal sympotoms were distributed into three groups：mosapride plus omeprazole 20mg/d （A group） , omeprazole 20mg/d（ B group） and mosapride plus omeprazole 20mg/d （C group）. The signs and sympotoms were estimated after fowlling - up 6 months. Results The difference was statistically significant （P 〈 0. 05） between A groups and B groups with regard to effective rate or cure rate for sympotom. The defference was statistically significant （P 〈 0.05） between C groups and B groups with regard to effective rate or cure rate for sympotom. However, the defference was not statistically significant （ P 〉 0.05 ） between A groups and C groups, but the cure rate of C groups was 18% high than that in the A groups. In addition,the difference was not statistically significant （ P 〉 0.05 ） between B groups and A groups with regard to effective rate for sign. The difference was not statistically significant （P 〉 0.05 ） between B groups and C groups with regard to effective rate for sign. However,the difference was statistically significant between B groups and C groups with regard to cure rate （P 〈 0.05）. Conclusion We suggest that mosapride plus double dose proton pump inhibitor may prove to be an effective method for treating extraesophageal sympotoms in patients with gastroesophageal reflux.

关 键 词：胃食管反流 咽部异常感觉 莫沙必利 质子泵抑制剂 

分 类 号：R57[医药卫生—消化系统]