SonicHedgehog信号通路在胎肺发育和肺部疾病中的研究进展  

Effect of Sonic Hedgehog signaling pathway on the embryonic lung development and lung diseases

作　　者：邵亚楠（综述）[1] 唐兰芳（审校）[1] 

机构地区：[1]浙江大学医学院附属儿童医院,杭州310003

出　　处：《国际儿科学杂志》2012年第2期203-205,211,共4页International Journal of Pediatrics

基　　金：国家自然科学基金资助项目（81070008、81170016）;浙江省自然科学基金资助项目（Y2100337）

摘　　要：SonicHedgehog（SHH）信号通路不仅在胚胎期发育起重要作用，而且在生后保持组织或器官的完整和功能发育中起重要作用。近年来在肺部疾病中发现SHH信号通路异常激活，提示SHH信号通路可能在肺部疾病中起一定作用。Sonic Hedgehog （SHH） signaling pathway not only plays key roles in embryonic develop- ment,but also functions in postnatal development and maintenance of tissue/organ integrity and function./n recent years,it has been found that the SHH signaling pathway was abnormally activated in some lung diseases, which suggested that the SHH signaling pathway may play a part in the development of some lung diseases. This article reviewed the potential role of SHH signaling pathway on the embryonic lunz develooment and lung diseases.

关 键 词：Sonic HEDGEHOG信号通路 胎肺发育 肺部疾病 

分 类 号：R542.2[医药卫生—心血管疾病]