Pokemon、Ki-67及Livin蛋白在胃癌中的表达及意义  

Expression and clinical signofocance of Pokemon,Ki-67 and Livin protein in gastric cancer

作　　者：李月锋[1] 曲宏岩[1] 张东欣[1] 

机构地区：[1]哈尔滨医科大学第三临床医学院胃肠外科,黑龙江哈尔滨150081

出　　处：《中国现代普通外科进展》2012年第3期179-182,共4页Chinese Journal of Current Advances in General Surgery

基　　金：黑龙江省哈尔滨市科技创新人才研究专项资金项目(2008RFQXS096)

摘　　要：目的:检测胃癌组织中Pokemon、Ki-67及Livin的表达,探讨其在胃癌的表达及意义。方法:应用Western-Blot方法检测80例胃癌标本及正常胃组织中Pokemon、Ki-67及Livin的表达。结果:胃癌组织中Pokemon、Ki-67及Livin的表达分别为67.5%(54/80)、42.5%(34/80)和52.5%(42/80)。正常胃组织中Pokemon、Ki-67及Livin的表达为12.5%(10/80)、7.5%(6/80)、11.3%(9/80)。胃癌组织中Pokemon、Ki-67、Livin的表达与临床TNM分期、淋巴结转移有关,与年龄、性别、部位、Borrman分型无关。Pokemon与Ki-67、Livin的表达呈正相关(P<0.05)。结论:Pokemon、Ki-67、Livin共同参与了胃癌的发生、发展和转移,可能成为胃癌临床诊断指标。Objective：To study the expression of Pokemon 、Ki-67、Livin and its clinical significant in gastric cancer and normal of gastric mucosa.Methods：The Pokemon,Ki-67 and Livin in gastric cancer（n=80）,normal gastric mucosa（n=80） was detected by Western-blot.Results：Pokemon protein expression was high in of cases in gastric cancer,which was significantly different from the expression in normal gastric mucosa,expression of Pokemon was relative to high and low of hyperplasia of gastric mucosa.It was highly expressed in gastric cancer and was related with stage of TNM and lymphoid node transfor.But were not related with the age,sex and the size of tumor.Conclusion：Pokemon,Ki-67 and Livin protein expression may be correlate with the carcinogenesis and genesis,development and metastasis of gastric cancer.Pokemon may be an effective target gene for therapy of gastric cancer,accordingly,which may develop a new way to gene therapy for gastric cancer.

关 键 词：胃肿瘤 pokemon蛋白 KI-67蛋白 LIVIN蛋白 

分 类 号：R735.2[医药卫生—肿瘤]