肾癌中miR-210的异常表达及意义  

Abnormal expression and significance of miR-210 in human renal cell carcinoma

作　　者：周亮[1] 冷慧敏[1,2] 翟庆娜[1,2] 王勇[1] 孙亮[1] 李贤新[1] 余振东[1] 桂耀庭[1] 

机构地区：[1]北京大学深圳医院男性生殖与遗传重点实验室,广东深圳518036 [2]汕头大学医学院

出　　处：《中国实验诊断学》2012年第3期468-471,共4页Chinese Journal of Laboratory Diagnosis

基　　金：2009年国家自然科学基金(编号:30900817);2009年深港创新圈计划(编号:ZYB200907080110A);2010年度深圳市科技研发资金基础研究计划资助项目(编号:JC201005260208A);深圳市生物;互联网;新能源产业发展专项资金-公共技术服务平台(编号:CXC201005260001A)

摘　　要：目的探讨miR-210在肾细胞癌发生过程中的作用。方法利用荧光定量PCR技术检测miR-210在52例不同阶段肾细胞癌及其癌旁组织中的表达量,并分析其与肾癌患者病理分期、年龄、性别的相关性。结果与相应癌旁组织相比,miR-210在肾癌组织中表达量显著上调(P=0.00),平均上调倍数为7倍。但miR-210上调倍数与肾细胞癌癌的病理分型、分期、年龄、性别均无显著相关。结论 miR-210在肾癌组织中表达明显上调,对肾癌的诊断和治疗具有潜在的意义。Objective Exploring the role of miR-210 in the development of renal cell carcinoma（RCC）.Methods Investigating the expression of miR-210 in 52 RCC and matched normal adjacent tissues by fluorescence quantitative PCR technology and analyzing the correlation between miR-210 expression and pathological stage,age and gender of RCC patients.Results Compared with the matched normal adjacent tissues,the expression of miR-210 was significantly increased（P = 0.00） in renal cell carcinoma tissues（the average：7 times）.However,miR-210 expression was not significantly correlated with advanced pathologic stages（P〉0.05）,age（P〉0.05） and gender（P〉0.05） of RCC patients.Conclusion The expression of miR-210 in RCC was significantly unregulated,which suggesting the potential significance for the diagnosis and treatment of RCC.

关 键 词：MIR-210 肾细胞癌 病理分期 

分 类 号：R737.11[医药卫生—肿瘤]