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作 者:王文[1] 张会东[1] 褚洁 王佩合[1] 孙瑞成[1] 邓卿[1] 马丽媛[1] 刘力生[1]
机构地区:[1]中国医学科学院阜外心血管病医院心血管病研究所,北京100037
出 处:《高血压杂志》2000年第1期58-61,共4页Chinese Journal of Hypertension
摘 要:目的:研究普乐林注射液对卒中型自发性高血压大鼠(SHRsp)脑卒中的预防和治疗作用。材料和方法:将80只8周龄(雌雄各半)SHRsp随机分为普乐林 200 mg/kg,100mg/kg及对照组,饮 1. 0%~1. 5% NaCl盐水。实验一:在高盐负荷开始即灌胃治疗,8周后断头处死,取颈动脉及脑组织做电镜检查。取脑组织光镜下检查脑卒中发生率。实验二:脑卒中发生后开始灌胃治疗,连续10天。记录大鼠脑卒中临床表现分数及存活天数。结果:实验一:治疗后普乐林 200 mg/kg, 100 mg/kg组颈动脉电镜扫描和脑组织电镜透射观察组织病理结果均好于对照组;光镜下脑卒中检出率(41.7%,50.0%)也低于对照组(76.9%)。实验二:治疗前脑卒中临床表现分数三组间相似,治疗后普乐林 200 mg/kg, 100 mg/kg组分数(0. 95±1. 39,2.41±1.65)均明显低于对照组(3.77±0.27)(P<0.01~0. 001)。治疗期存活天数普乐林 200 ms/kg组(9. 73±1.03)及100 mg/kg组(7.93±2.64)均长于对照组(5.36±4.45)(P<0. 05, P>0. 05)。脑与心脏重量?Aim: The study is to investigate the preventive and treatment effects of puerarin (PR) on stroke in strokeprone spontaneously hypertensive rats (SHRsp). Methods:Eighty SHRsp of 8 week old were randomly divided into PR 200 mg/kg, 100 mg/kg and control group. Rats were given 1. 0% - 1. 5 % NaCl as drinking fluid ad libido. In ex- periment 1: rats were given PR 200 mg/kg·dm^(-1), 100 mg/kg· d^(-1) or water control at the beginning of experiment for 8 weeks. The histopathologic examination of their brain and carotid artery was made after decapitation. In experiment 2: after onset of stroke, rats were given orally PR 200 mg/kg· d^(-1), 100 mg/kg ·d^(-1) or water control for 10 days. The clinical score of stroke and survival time of rats were recorded. Results: In experiment 1: the incidence of stroke by microscopy in PR 200 mg/kg and 100 mg/kg group was 41. 7% and 50. 0% respectively, that was decreased than control group (76. 9% ). Electron microscope study showed the endothelium of carotid artery were normal in 200 mg/kg group, while it was seriously injured in control group and mildly injured in PR 100 mg/kg group. The brain morphological study showed normal in PR 200 mg/kg group, significant neuron damage were found in the control. In experiment 2: the clinical scores of stroke after treatment with PR 200 mg/kg and 100 mg/kg group were 0. 95 ± 1. 39 and 2. 41 ± 1. 65 respectively, that is lowered than control group (3. 77 ± 0. 27, P<0. 01). The survival time in PR 200 mg/kg 9. 7± 1. 0 day and PR 100 mg/kg 7. 9± 2. 6 day that is longer than control group (5. 36± 4. 45 day,P<0. 05). Conclusion:PR may prevent and effectively treat the stroke in SHRsp.
分 类 号:R743.3[医药卫生—神经病学与精神病学]
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