利培酮对脑电图影响的研究  

Electroencephalogram (EEG) in patients treated by risperidone

作　　者：万艳琼[1] 郑瞻培[1] 谢斌[1] 袁伊春[1] 王玉蓉[1] 

机构地区：[1]上海市精神卫生中心,200030

出　　处：《临床精神医学杂志》2000年第1期22-23,共2页Journal of Clinical Psychiatry

摘　　要：目的:研究利培酮引起脑电图改变的特征,其改变与用药时间、剂量及疗效之间关系,并与氯氮平引起的脑电图异常作一比较。　方法:符合CCMD2R诊断的精神分裂症、分裂样精神病患者入组。在服药前、服药后1周、2周、4周分别检查脑电图,并记录用药剂量,测定简明精神病评定量表(BPRS)观察疗效。　结果:服用利培酮后脑电图波率变慢,服用1周后即出现脑电图异常(P<001),与剂量及疗效无关,异常率及异常程度轻于氯氮平(P<001)。Objective:To study EEG features of patients treated by risperidome and the relationship between EEG and the period of administration,dosage and clinical response.The comparison group took in clozapine. Method:EEG,risperidone dosage,efficacy (BPRS scores) were recorded in patients with diagnosis of schizophrenia,schizophreniform psychosis according to CCMD 2 R before and after using risperidone. Results:The basic electric activities of EEG became slow after using risperidone.There were no association between dosage and clinical response. Conclusion:The abnomal EEG was lesser serious in risperidone than clozapine.

关 键 词：利培酮 脑电图 氯氮平 

分 类 号：R741.044[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]