成人非酒精性脂肪肝与高尿酸血症关系的研究  

Research on the Relationship between Non-alcoholic Fatty Liver Disease and Hyperuricemia in Adults

作　　者：秦恳[1] 马秀英[2] 周婷[1] 张帆[1] 吴琴琴[1] 曾莉[1] 杨英[1] 黄燕[1] 邹天富[1] 李李[1] 王佑娟[1] 

机构地区：[1]四川大学华西医院体检中心,成都610041 [2]四川大学基础与法医学院,成都610041

出　　处：《华西医学》2012年第2期226-229,共4页West China Medical Journal

摘　　要：目的了解成都地区非酒精性脂肪肝(NAFLD)及高尿酸血症(HUA)患病情况及相关因素。方法对2010年9月-2011年3月健康体检的36 000名18岁以上受检者,进行病史采集、体格检查、空腹血糖、血脂、肝功能、肾功能、血尿酸检测以及上腹部彩色多普勒超声检查。结果高尿酸血症(HUA)的总患病率为18.17%。NAFLD患者HUA患病率为39.41%,明显高于总患病率(P<0.01)。NAFLD患者的HUA患病率随体质量指数(BMI)的增加呈递增趋势。BMI、舒张压、甘油三酯、胆固醇、丙氨酸转氨酶、门冬氨酸氨转移酶、谷氨酰转肽酶、血肌酐、胱抑素C均随着血尿酸水平的升高而递增;高密度脂蛋白随着血尿酸水平的升高而递减。结论 NAFLD及HUA关系密切,且二者与代谢紊乱联系紧密。Objective To learn the characteristics of non-alcoholic fatty liver disease（NAFLD） and hyperurcemia（HUA） in Chengdu area,and analyze the relevant factors.Methods A total of 36 000 adults aged over 18 who did health examinations in our hospital from September 2010 to March 2011 were studied.We investigated their disease history and collected their general physical data.Fasting plasma glucose,serum lipids,liver functions,kidney functions,and serum uric acid were detected,and upper abdominal ultrasonographic examination was carried out.Results The total prevalence of HUA was 18.17%.The prevalence of HUA was 39.41% in NAFLD patients,which was much higher than the total prevalence（P〈0.01）.The prevalence of HUA in NAFLD patients increased with the body mass index（BMI）.BMI,diastolic blood pressure,triglyceride,cholesterol,alanine transaminase,aspartate amino transferase,gamma-glutamyl transferase,serum creatinine,and serum cystatin C were all up along with the increase of serum uric acid,while the level of HDL-C decreased.Conclusion There is a close relationship between NAFLD and HUA in adults;NAFLD and HUA are inseparably associated with metabolic disorder.

关 键 词：非酒精性脂肪肝 高尿酸血症 成年人 

分 类 号：R575.5[医药卫生—消化系统]