大蒜素抑制脑缺血再灌注诱导细胞凋亡机制的研究进展  

Research Progress of Allicin Inhibition on Mechanisms of Cerebral Ischemia-Reperfusion Induced Apoptosis

作　　者：黄冬冬[1] 孙玉敏[1] 刘志金[1] 李清君[2] 郭莉华[3] 

机构地区：[1]沧州医学高等专科学校,河北沧州061001 [2]河北医科大学,河北石家庄050017 [3]邢台医学高等专科学校,河北邢台054000

出　　处：《现代生物医学进展》2012年第4期755-756,共2页Progress in Modern Biomedicine

摘　　要：脑缺血再灌注损伤的主要机制是多种因素诱导的神经元凋亡。近些年来,大蒜素以其脂溶性好,可通过血脑屏障,并具有多种生物功效比如被用于抗细菌、病毒和真菌的感染,尤其是其对于脑保护的作用日益受到重视。本文主要对大蒜素抑制脑缺血再灌注诱导的细胞凋亡的作用及其机制方面做一综述。The main mechanism of Cerebral ischemia-reperfusion injury is a variety of factors induced neuronal apoptosis.In recent years,Allicin is more and more attentioned for its fat-soluble extract,passing through blood-brain barrier,and a variety of biological effects such as anti-bacterial,viral and fungal infections,particularly its role in brain protection.This paper mainly rewed the reviallicin inhibition on cerebral ischemia-reperfusion induced apoptosis and its mechanisms.

关 键 词：脑缺血再灌注 细胞凋亡 大蒜素 

分 类 号：R285.5[医药卫生—中药学] R743[医药卫生—中医学]