应用透光度观察黄连对离体人牙根管内粪肠球菌体外抑菌效果  

Inhibiting Effects of Coptis Chinensis Franch on Enterococcus Faecium with Transmittances

作　　者：于静[1] 

机构地区：[1]石家庄市第二医院口腔科,石家庄050051

出　　处：《临床误诊误治》2012年第3期62-64,共3页Clinical Misdiagnosis & Mistherapy

基　　金：河北省2011年医学科学研究重点课题计划(20110184)

摘　　要：目的观察黄连水煎剂对离体人牙根管内粪肠球菌的体外抑菌效果。方法选取48颗新鲜拔除的人单根管牙,随机分为黄连组、甲醛甲酚(FC)组、阴性对照组和阳性对照组,每组12颗。常规根管预备后灭菌,黄连组、FC组和阳性对照组制备感染粪肠球菌根管模型,阳性对照组放置0.9%氯化钠注射液,另两组分别放置黄连水煎剂和FC液,3 d、7 d后分别培养并测量细菌的透光度。阴性对照组根管内置入0.9%氯化钠注射液,直接测量透光度。结果培养3 d,黄连组与FC组细菌透光度差异无统计学意义(P>0.05);培养7 d,黄连组与FC组细菌透光度差异无统计学意义(P>0.05)。3 d、7 d时黄连组、FC组与阳性对照组和阴性对照组比较差异均有统计学意义(P<0.05)。结论黄连水煎剂对人牙根管内粪肠球菌体外抑菌效果与FC相同。Objective To observe the inhibiting effects of Coptis Chinensis Franch decoction on enterococcus faecium in the infected root canals.Methods A total of 48 single-rooted extracted human teeth were used in this study,which were randomly divided into Coptis Chinensis Franch group,FC group,negative control group,and positive control group.Each group had 12 teeth.The enterococcus faecium infected root canal models were manufactured after normal root canal preparation and sterilization.The teeth of negative control group was not infected by bacteria,and placed in 0.9% sodium chloride injection fluid.The other teeth were infected by enterococcus faecium.The teeth of positive control group was placed in 0.9% sodium chloride injection fluid and the other two groups were treated with Coptis Chinensis Franch decoction and FC separately.Transmittances of each group were measured 3 days and 7 days later.Results The Transmittances of Coptis Chinensis Franch group and FC group on D3 showed no significant difference（P0.05）,and there was no significant difference between Coptis Chinensis Franch group and FC group on D7（P0.05）.Coptis Chinensis Franch group and FC group were compared with negative control group and positive control group separately,and the difference had statistical significance（P0.05）.Conclusion Coptis Chinensis Franch has the same inhibition effects as enterococcus faecium FC.

关 键 词：肠球菌 粪 牙髓腔 黄连 抑菌作用 

分 类 号：R781.05[医药卫生—口腔医学] R781.202.5[医药卫生—临床医学]