毒黄素对小鼠肾脏毒性作用的超微病理观察  

Ultrapathological observation of toxic effect of toxoflavin on kidney of experimental mice

作　　者：吴洪娟[1] 李锋杰[1] 张圣明[1] 

机构地区：[1]潍坊医学院形态学实验室,山东潍坊261053

出　　处：《电子显微学报》2012年第1期51-55,共5页Journal of Chinese Electron Microscopy Society

摘　　要：观察毒黄素对小鼠肾脏的超微病理改变,探讨毒黄素中毒的机理。小鼠腹腔注射毒黄素(1.5 mg/kg),2 h后取其肾皮质,应用电子显微镜观察其超微结构改变。电镜下可查见毒黄素主要损伤肾近曲小管上皮细胞的线粒体和毛细血管内皮细胞基底膜,表现为大量线粒体空泡化和毛细血管基底膜不匀性增厚。毒黄素可造成肾近曲小管上皮细胞和肾小球毛细血管内皮细胞的超微结构损伤,以线粒体和基底膜的损伤更为突出,为毒黄素的毒性作用提供超微形态学依据。To observe the ultrapathological changes of mice kidney after toxoflavin（TXF） intoxication.TXF（1.5mg/kg） was injected into the peritoneal cavity of mice.The cortex of kidney was taken after 2 h of intoxication for ultrathin section and the ultrastructural changes were observed by using transmission electron microscopy.TXF can injure the epithelial cells of proximal tubules as well as the endothelium,podocyte and intraglomerular mesangial cells of glomerulus of kidney of experimental mice.The mitochondria of the epithelial cells of proximal tubules and the basement membrane of endothelial cells of glomerulus are the main injured organelles.The toxic effect of TXF on experimental mice is probably to injure the inner membrane system of mitochondria and capillary basement membrane.The results provided ultramorphological evidence on mechanism of TXF intoxication.

关 键 词：毒黄素 肾 超微结构 中毒 

分 类 号：R114[医药卫生—卫生毒理学] S858.91[医药卫生—公共卫生与预防医学]