饮用咖啡与2型糖尿病队列研究的meta分析  

Coffee consumption and type 2 diabetes mellitus:a meta-analysis of prospective cohort studies

作　　者：石瑀[1] 董加毅[1] 张增利[2] 王培玉[3] 张卫国 秦立强[1] 

机构地区：[1]苏州大学医学部公共卫生学院营养与食品卫生教研室,江苏苏州215123 [2]苏州大学医学部公共卫生学院毒理教研室,江苏苏州215123 [3]北京大学医学部公共卫生学院社会医学与健康教育系,北京100191 [4]雀巢研究中心北京分部 [5]北京雀巢研发中心有限公司,北京100095

出　　处：《苏州大学学报（医学版）》2012年第1期89-94,119,共7页Suzhou University Journal of Medical Science

基　　金：江苏省"青蓝工程"优秀青年骨干教师培养对象科研资助项目(Bu126801)

摘　　要：目的探讨饮用咖啡与2型糖尿病发生的关系。方法在Pubmed中用"coffee"和"diabetes"搜索研究咖啡与2型糖尿病风险的前瞻性队列研究,抽取每个研究中咖啡饮用最高量与最低量(参考水平)相比较的相对危险度(RR)和95%可信区间(CI),运用meta分析估算汇总RR值及95%CI,并进行分层分析和灵敏度检验。结果发表时间在2002年至2011年的26个前瞻性队列研究纳入本meta分析,总共包括30个独立研究,总观察对象为1 025 870名,糖尿病患者37 187名,26个研究中的研究对象的随访时间在2.6年至20年之间(中位时间为11年)。和对照比较,每日饮用咖啡的RR值为0.69(95%CI 0.64,0.75)。按地区、性别、随访年限和患者诊断方式分层后,RR无明显波动。结论每日饮用咖啡可以降低31%的糖尿病发病风险。Objective To analyze the overall pooled estimates of the effect of coffee consumption on the risk of type 2 diabetes （T2DM）. Methods The PubMed database was searched using search terms ＂coffee＂ and ＂diabetes＂ for published cohort studies in English language. The prospective studies in which observed the association of coffee consumption was observed with T2DM risk were selected for metaanalysis. The relative risk （RR） and 95% confidence interval （CI） were compared for the highest and lowest/referential category of consumption. Subgroup and sensitivity analysis was performed in this metaanalysis. Results There were 26 articles （from 2002 to 2011 ） including 30 independent studies eligible for the present meta-analysis. The total number of cases was 1 025 870, among which 37 187 new cases of T2DM were documented during the period from 2.6 to 20 （ median 11 ） years of follow-up. The summary RR was 0.69 （95 % CI 0.64, 0.75 ） when the highest was compared with the lowest consumption category. The summary RR remained almost unchanged rthrough the subgroup analysis. Conclusion The findings indicate that long-term coffee consumption results in 31% reduction of T2DM risk.

关 键 词：咖啡 糖尿病 META分析 

分 类 号：R587.1[医药卫生—内分泌]