TGF-β信号通路与胶质细胞瘤生物学行为的关系  

The Relationship between TGF-β Signal Pathway and Tumor Cells' Biological Characteristics in Glioma

作　　者：曹响元[1] 赵耀东[1] 楼美清[1] 

机构地区：[1]上海市第十人民医院神经外科,上海200072

出　　处：《中国神经肿瘤杂志》2012年第1期51-57,共7页Chinese Journal of Neuro-Oncology

摘　　要：TGF-β信号通路在肿瘤形成早期发挥抑制作用,但随着肿瘤进展其作用转换为促进肿瘤进展,目前其具体机制尚不清楚。本文对TGF-β信号通路与胶质细胞瘤增殖、迁移、侵袭、肿瘤免疫抑制及胶质瘤干细胞的关系作一综述。Initially,transforming growth factor β（TGF-beta） acts as a growth inhibitory factor at the early stages of tumor development,but after stages of progress,tumor masses develop mechanisms to evade the growth-regulatory effects of TGF-beta,resulting in extensive tumor invasiveness,increased metastatic potential and inhibition of surrounding immune responses.Although TGF-beta signal pathway has been extensively studied,the molecular mechanisms that trigger tumor cells to ＂switch＂ from TGF-beta-inhibition to TGF-beta-promotion are still not completely understood.This review summarized the current molecular mechanisms involved in the tumor suppression,tumor progression,tumor invasion and tumor immunity characteristics of TGF-beta in glioma.

关 键 词：转化生长因子(TGF-β) 信号通路 神经胶质瘤 肿瘤干细胞 

分 类 号：R739.41[医药卫生—肿瘤]