非线性超声场中医用微泡的空化预测研究  

Research on the Prediction of Inertial Cavitation of the Medical Microbubbles in Nonlinear Ultrasound Field

作　　者：胡继文[1] 唐祥德[2] 陈铀[1] 郭萍[1] 

机构地区：[1]南华大学数理学院,湖南衡阳421001 [2]衡阳师范学院数学系,湖南衡阳421008

出　　处：《河南大学学报（自然科学版）》2012年第2期134-138,143,共6页Journal of Henan University:Natural Science

基　　金：湖南省教育厅科学资金资助项目(10C1163);湖南省市联合科学资金重点项目资助(10JJ8005)

摘　　要：以两种常见医用微泡的实验材料为计算参数,利用修正的Rayleigh-Plesset方程,对粘滞流体中不同半径的医用微泡在非线性超声波驱动下的空化行为进行了数值仿真.结果表明:一定驱动声频下,声压越大,医用微泡的空化概率越大,且向半径减小的方向移动,其空化概率受微泡材料参数影响也较大;同时,声作用周期个数越多,空化概率越大.当声作用周期个数增到一定数量时,其空化概率达到饱和.Using experimentally determined values as parameters and a modified Rayleigh-Plesset equation,we compute the cavitation kinetics of medical microbubble of different size driven by nonlinear wave in viscous fluid.The results show that the occurrence probability of cavitation（OPC） will increase with sound pressure and drifts in the direction of radius reduced under an exciting frequency.The OPC is also correlated significantly with material parameters of microbubble.The more the cycle number of ultrasonic is,the larger the OPC has become,and the OPC can be close to full cavitation as cycles of ultrasonic reaches a specified number.The OPC may provide a theoretical basis for determining the ultrasound contrast agent（UCA） sizes in different bubble-enhanced biomedical applications.

关 键 词：医用微泡 非线性超声场 空化预测 

分 类 号：TP391[自动化与计算机技术—计算机应用技术]