中国东北地区遗传性非息肉病性结直肠癌家系肠外肿瘤谱特点分析  

Analysis of Features of Extracolonic Carcinoma Spectrum in Northeast Chinese with Hereditary Nonpolyposis Colorectal Cancer

作　　者：李晓霞[1] 唐元新[1] 孙公平[1] 李鑫 赵萌[1] 闫一飞[1] 孟金[1] 

机构地区：[1]中国医科大学附属第四医院胃肠外科,辽宁沈阳110032

出　　处：《中国普外基础与临床杂志》2012年第3期288-291,共4页Chinese Journal of Bases and Clinics In General Surgery

基　　金：辽宁省教育厅高等学校科研项目(项目编号:2008-781);2011年辽宁省自然科学基金项目(项目编号:201102281)~~

摘　　要：目的探讨东北地区遗传性非息肉病性结直肠癌(HNPCC)家系肠外肿瘤谱的特点。方法对登记的85个严格符合Amsterdam标准Ⅱ的HNPCC家系肠外肿瘤谱特点进行回顾性分析。结果 85个家系中,肿瘤患者509例,原发癌灶589例次,其中结肠癌219例,直肠癌91例,肠外肿瘤279例,肠外肿瘤最常见为肺癌。结论肠外肿瘤是HNPCC家系肿瘤谱的重要组成部分,东北地区常见的肠外肿瘤依次为肺癌、胃癌、子宫内膜癌、肝癌和食管癌。Objective To investigate the features of extracolonic carcinoma spectrum in Northeast Chinese with hereditary nonpolyposis colorectal cancer.Methods The extracolonic carcinoma spectrum’s characteristics of 85 families registered in strict conformity with the HNPCC Amsterdam criteria Ⅱ were analyzed retrospectively.Results In the 85 HNPCC families,the tumorous patients were 509 cases,the primary tumors were 589 cases,among the total consisted of 219 cases of colon cancer,91 cases of rectal cancer,and 279 cases of extracolonic cancer,the most common extracolonic carcinoma was lung cancer.Conclusions Extracolonic carcinoma is an important part of cancer spectrum in HNPCC family,and the common extracolonic carcinoma in Northeast of Chinese are lung cancer,gastric cancer,endometrial cancer,liver cancer,and esophagus carcinoma.

关 键 词：遗传性非息肉病性结直肠肿瘤 肠外肿瘤 特点 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]