不同ABCD^2评分短暂性脑缺血发作患者降纤、抗凝治疗的疗效比较  

Therapeutic effectiveness of the defibrase and anticoagulant on transient ischemic attack(TIA) scored by different ABCD^2

作　　者：陈艳坤[1,2] 刘诗翔[1] 孔繁一[1] 王泽祥[1,2] 

机构地区：[1]成都军区昆明总医院,昆明650032 [2]昆明医学院临床学院

出　　处：《山东医药》2012年第9期20-22,共3页Shandong Medical Journal

基　　金：云南省应用基础研究自筹经费项目(2010ZC185)

摘　　要：目的比较不同ABCD2评分短暂性脑缺血发作(TIA)患者降纤、抗凝治疗的疗效。方法选择173例TIA患者,进行ABCD2评分分层。根据治疗方案不同分为降纤组93例、抗凝组80例。比较两组7 d内疗效、不同ABCD2评分分层下疗效及随访1年内结局。结果降纤组治疗7 d总有效率为87.10%,抗凝组为70.00%,两组比较P<0.05。ABCD2评分4～5分的TIA患者采用两种治疗方案治疗3～7 d,显效率比较有统计学意义(P<0.05),随访1年时两组结局无统计学意义。结论 TIA发作后3～7 d、ABCD2评分4～5分的患者使用降纤治疗较抗凝效果更好。Objective To compare the therapeutic effectiveness of the defibrase and anticoagulant on transient ischemic attack （TIA） scored by different ABCD^2. Methods 173 patients with TIA onset were selected and scaled by ABCD^2. 93 cases received defibrase and the other 80 cases received anticoagulants. Patients were followed for one year. Results The total rate of availability is 87.10% in defibrase group within 7 days, while 70.00% in anticoagulant group （ P 〈 0.05 ）. For patients with an ABCD2 score of 4 to 5, a significant difference was observed between two treatments at the seconde resuh （P 〈 0.05 ）. Defibrase was not superior to anticoagulants at one-year follow up. Conclusions Patients with TIA onset within 3 to 7 days and ABCD2 score within 4 to 5 would benefit more from defibrase than anticoagulants.

关 键 词：脑缺血发作 短暂性 ABCD2评分 降纤治疗 抗凝治疗 

分 类 号：R743.31[医药卫生—神经病学与精神病学]