VEGF、PTN在肺癌患者外周血及胸腔积液中表达及其意义  

Expression and Significance of VEGF、PTN in Pleural Effusion and Peripheral Blood of Patients with Lung Cancer

作　　者：林琳[1] 哈敏文[1] 

机构地区：[1]辽宁医学院,辽宁锦州121001

出　　处：《科技通报》2012年第2期27-28,60,共3页Bulletin of Science and Technology

基　　金：辽宁省教育厅科研课题项目(L2010286)

摘　　要：目的:以45名肺癌伴胸腔积液患者,50名肺癌组不伴胸腔积液患者,以及19名健康人为研究对象,探讨VEGF、PTN在肺癌患者外周血及胸腔积液中表达及其意义。方法:以ELISA法测定胸腔积液中VEGF及PTN表达水平。结果:肺癌伴胸腔积液组患者胸腔积液及外周血中VEGF、PTN表达水平明显高于肺癌不伴胸腔积液组和健康对照组外周血。差异有统计学意义(P<0.05)。结论:肺癌患者胸腔积液及外周血中VEGF、PTN表达明显升高,可能通过某一共同机制促进肿瘤转移、恶化。Objective,To explore the expression and elinical signfieance of VEGF,PTN in pleural effusion and peripheral blood of patients with lung cancer. Methods,Numbers of VEGF,PTN was detected with the ELISA, using the Malignant pleural effusion and peripheral blood from 45 lung cancer with Malignant pleural effusion,50 lung cancer patients and 19 healthy people as samples. Results,The level of VEGF,PTN in Malignant pleural effusion and peripheral blood from lung cancer with Malignant pleural effusion was higher than that of cancer patients and healthy people （P〈0.05）.Conclusion, The level of VEGF,PTN in pleural effusion and peripheral blood of patients with lung cartcer was Significantly increased, possibly through a common mechanism to promote tumor metastasis and worse.

关 键 词：血管内皮生长因子 多效蛋白 肺癌 胸腔积液 

分 类 号：R734.2[医药卫生—肿瘤]