脑胶质瘤术后晚期癫痫发生的危险因素分析  

Predisposing factors of post-operative tardive epilepsy in patients with brain glioma

作　　者：公方和[1] 王国良[1] 王伟民[1] 

机构地区：[1]广州军区广州总医院神经外科,广东广州510010

出　　处：《中华神经外科疾病研究杂志》2012年第1期66-68,共3页Chinese Journal of Neurosurgical Disease Research

摘　　要：目的探讨胶质瘤术后晚期癫痫发生的危险因素。方法回顾分析接受手术并有完整临床资料的胶质瘤病例305例,以性别、年龄、主要症状、阳性体征、术前癫痫、病变部位、手术入路、动静脉损伤、肿瘤残留、术后水肿、病理性质、早期癫痫、病变复发、手术次数、放射治疗等15项可能的影响因素为自变量,设定术后"发生晚期癫痫"为因变量,使用Logistic逐步回归分析研究相关的影响因素。结果术前癫痫、病变部位、肿瘤残留、病变复发、术后水肿5个因素是术后晚期癫痫发生的危险因素。结论胶质瘤患者术后晚期癫痫的发生影响患者的生活质量,针对晚期癫痫发生危险因素的防治,有利于减少胶质瘤术后晚期癫痫的发生,从而改善患者的生活质量。Objective To explore the predisposing factors of post-operative tardive epilepsy in patients with glioma.Methods The complete clinical data of 305 patients with glioma were analyzed retrospectively.Gender,age,predominant symptoms,positive signs,pre-operative epilepsy,location,surgical approaches,injury of artery and vein,residual glioma,post-operative edema,pathology of glioma,post-operative early-epilepsy,recurrence,frequency of operation,radiotherapy were analyzed as the dependent variables in Logistic regression to identify the risk factors of post-operative tardive epilepsy.Results History of pre-operative epilepsy,location,residual glioma,glioma recurrence,post-operative edema were identified as the risk factors for post-operative tardive epilepsy in glioma patients.Conclusion Post-operative tardive epilepsy affects the quality of life of patients,and the prevention and treatment for the risk factors may decrease the occurrence of post-operative tardive epilepsy and improve the quality of life.

关 键 词：胶质瘤 晚期癫痫 危险因素 

分 类 号：R739.45[医药卫生—肿瘤] R742.1[医药卫生—临床医学]