脑源性神经营养因子Va166Met基因多态性与首发精神分裂症临床特征的关联研究  

Association study of brain-derived neurotrophic factor Va166Met polymorphism and clinical characteristics of first episode schizophrenia

作　　者：孙萌萌[1] 刘兰芬[2] 杨丽敏[2] 王妍[1] 崔开艳[2] 王丽娜[2] 李翠鸾[2] 乔冬冬[2] 王汝展[2] 

机构地区：[1]山东大学医学院,济南250012 [2]山东省精神卫生中心

出　　处：《中华医学遗传学杂志》2012年第2期155-158,共4页Chinese Journal of Medical Genetics

基　　金：基金项目：山东省自然科学基金（ZR2009CL012）

摘　　要：目的探讨脑源性神经营养因子（brain—derivedneurotrophicfactor，BDNF）基因Val66Met多态性与首发精神分裂症临床特征的关联性。方法应用TaqMan荧光探针技术对135例首发精神分裂症患者及483名正常对照者进行基因分型；采用阳性与阴性症状量表（positiveandnegativesyndromescale，PANSS）评估精神分裂症患者临床特征。结果精神分裂症患者组与正常对照组BDNFVal66Met基因型及等位基因分布频率的差异具有统计学意义（P〈0．01）；Met／Met基因型患者的PANSS总分、焦虑（抑郁）因子分及认知损害因子分均高于Val／Val和Val／Met基因型患者，差异有统计学意义（P〈0．01）。结论BDNF基因Val66Met多态性可能与精神分裂症的发病有关；首发精神分裂症患者中Met／Met基因型者临床症状可能更重。Objective To assess the association between brain-derived neurotrophic factor （BDNF） gene Va166Met polymorphism and clinical characteristics of first episode schizophrenia in a Chinese Han population. Methods Genotyping of BDNF Va166Met polymorphism was carried out for 135 schizophrenic patients and 483 healthy controls with TaqMan probe technology. The patients＇ psychotic symptoms were assessed using the positive and negative syndrome scale （PANSS）. Results A significant difference was found in genotype distribution and allelic frequency of the Va166Met polymorphism between the two groups （P〈0.01）. In patients, Met homozygotes had a significantly higher score in anxiety/depression factor, cognitive factor and total score of PANSS than Val carriers. Conclusion BDNF gene Va166Met polymorphism is associated with the pathogenesis of schizophrenia. The Met/Met genotype of BDNF Va166Met variant may be a risk factor for symptoms in first episode schizophrenia patients.

关 键 词：脑源性神经营养因子 精神分裂症 单核苷酸多态性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]