我院103例正畸青少年患者牙龈炎抗生素药物治疗的临床研究  

Clinical Study of Antibiotics Therapy for Gingivitis in 103 Adolescent Orthodontic Patients in Our Hospital

作　　者：袁文红[1] 潘洪祥[1] 石杰[1] 

机构地区：[1]青岛市市立医院口腔科,山东青岛266071

出　　处：《中国药房》2012年第14期1299-1301,共3页China Pharmacy

摘　　要：目的:为正畸青少年牙龈炎患者选择疗效确切、毒副作用轻微的抗生素治疗方案提供参考。方法:将103例患者随机分为阿奇霉素组、阿莫西林组、克林霉素组,将临床有效率以及龈沟液中天门冬酸氨基转移酶作为评价指标。结果:阿莫西林组的有效率较阿奇霉素组高(P<0.05),其他2组之间差异无统计学意义(P>0.05);阿莫西林组与克林霉素组治疗后龈沟液中天门冬酸氨基转移酶水平均较治疗前明显降低(P<0.05);3组不良反应发生率差异无统计学意义(P>0.05)。结论:青少年牙龈炎患者应用抗生素的倾向性由高到低依次为阿莫西林、克林霉素、阿奇霉素。OBJECTIVE：To provide a reasonable antibiotic treatment project with accurate efficacy,minor side effects for the adolescent orthodontic patients with gingivitis.METHODS：103 patients were randomly divided into azithromycin group,amoxicillin group and clindamycin group.Aspartate aminotransferase level of the gingival crevicular fluid（GCF-AST） and the clinical effective rate were used as evaluation indexes.RESULTS：Effective rate of amoxicillin group was significantly higher than azithromycin group（P〈0.05）,there was no statistical significance between other 2 groups（P〉0.05）;the level of GCF-AST in amoxicillin group and clindamycin group after treatment was significantly lower than before（P〈0.05）;meanwhile,the incidence of adverse drug reactions showed no significant difference among 3 groups（P〉0.05）.CONCLUSION：Clinical use of antibiotics in descending order of preference is amoxicillin,clindamycin,azithromycin for adolescent patients with gingivitis.

关 键 词：青少年 牙龈炎 抗生素 临床研究 

分 类 号：R969.4[医药卫生—药理学] R988.2[医药卫生—药学]