小剂量紫杉醇联合顺铂在宫颈癌根治性放疗中的应用  

Prospective study of low dose Paclitaxel and Cisplatin for treatment of advanced cervical cancer

作　　者：王文翔[1] 范文强[2] 董学彩[1] 马瑞霞[1] 陈彩霞[1] 

机构地区：[1]河南省新乡市中心医院妇科妇瘤科,河南新乡453000 [2]河南省新乡市中心医院风湿免疫科,河南新乡453000

出　　处：《中国医药导报》2012年第9期85-86,共2页China Medical Herald

摘　　要：目的探讨小剂量紫杉醇、顺铂联合放疗对Ⅱa～Ⅲb期宫颈癌的疗效及副反应。方法将65例宫颈癌患者分为TP1组和TP2组,TP1组:紫杉醇60 mg/m2,顺铂20 mg/m2,每8～10天重复。TP2组:紫杉醇135 mg/m2,顺铂60 mg/m2,化疗间隔21 d。同步行根治性放射治疗,比较其近期疗效及副反应。结果①两组有效率相当,皆为100%;②TP1组总治疗时间明显短于TP2组(P<0.05);③不良反应主要为血液毒性、消化道反应,TP1组发生严重骨髓抑制少于TP2组(P<0.05)。肌肉关节痛,脱发常见。结论小剂量紫杉醇(60 mg/m2)联合顺铂(20 mg/m2)方案在宫颈癌根治性化疗中值得推荐。Objective To compare the efficacy and toxicity of different dose Paclitaxel and Cisplatin for advanced cervical cancer in stage Ⅱa-Ⅲb.Methods 65 patients with advanced cervical cancer were divided into TP1 group and TP2 group.TP1 group： Taxol 60 mg/m2,Cisplatin 20 mg/m2,repart every 8-10 days.TP2 group： Taxol 135 mg/m2,Cisplatin 60 mg/m2,the interval was 21 days.Results ①The overall response rate（CR＋PR） was 100%,TP1 group was equivalent of TP2 group;②TP1 group was less than TP2 group in the average course of treatment period（P 0.05）;③the major side effects were hematological toxicity and gastroenteric reactions.The hematological toxicity was more common in TP2 group than TP1 group（P 0.05）.Neurotoxicity and alopecia were similar between two groups.Conclusion Paclitaxel（60mg/m2） plus Cisplatin（20 mg/m2） is worth to be recommended in concurrent chemoradiotheapy for advanced cervical cancer.

关 键 词：宫颈癌 根治性放疗 紫杉醇 顺铂 小剂量 

分 类 号：R737[医药卫生—肿瘤]