MKK4基因启动子区-1304T>G多态与食管癌易感性研究  

No association between the functional polymorphism(-1304T>G) in the MKK4 gene and the risk of esophageal cancer

作　　者：冯飞跃[1] 郑健[2] 姜岚[2] 游永鹤[2] 周翊峰[2] 

机构地区：[1]中国医学科学院北京协和医学院肿瘤医院肿瘤研究所胸外科,北京100021 [2]苏州大学基础医学与生物科学学院癌症分子遗传实验室,江苏苏州215123

出　　处：《中华肿瘤防治杂志》2012年第2期88-91,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家自然科学基金面上项目(81171895)

摘　　要：目的:探讨MKK4基因-1304T>G位点单核苷酸多态基因型在中国东部人群中的分布及其对食管癌易感性的影响。方法:设计以医院为基础的病例对照研究,进行食管癌患者与对照人群频数匹配,采用聚合酶链反应-限制性片段长度多态性的方法(PCR-RFLP)对571例食管癌患者和785名正常人的MKK4基因-1304T>G位点(rs3826392)进行基因分型。利用Logistic回归分析基因多态性与食管癌发病风险的关联,并校正年龄和性别。结果:MKK4基因-1304T>G位点基因多态性在病例和对照组中分布差异无统计学意义,GG基因型(OR=0.98,95%CI:0.67～1.61),TG基因型(OR=1.12,95%CI:0.90～1.43),P=0.435。结论:MKK4基因-1304T>G位点的单核苷酸多态可能与中国东部人群食管癌易感性无关。OBJECTIVE： To detect the association between the functional polymorphism （-1304T〉 G） of the MKK4 gene and the risk of esophageal cancer in Eastern Chinese population. METHODS： A hospital based case-control study was carried out in Eastern Chinese populations, totally contain 571 esophageal cancer patients and 785 age and sex matched controls by using polymerase chain reaction-restriction fragment length polymorphism （PCR RFLP） method. RESULTS： No significant association was observed between the -1304T〉G polymorphism genotypes and esophageal cancer risk （GG： OR=0.98,95%CI：0.67-1.61; TG： OR=1. 12, 95%CI：0. 90-1. 43; P=0. 435）. CONCLUSION： It suggests that the genetic variant MKK4 -1304T〉 G may not as a causative factor for the susceptibility of esophageal cancer in Eastern Chinese population.

关 键 词：食管癌 MKK4 基因多态性 

分 类 号：R735.1[医药卫生—肿瘤]