AOM/DSS模型与炎症相关癌变研究进展  

Advances in research of inflammation-associated carcinogenesis based on the AOM/DSS murine model

作　　者：林凯璇[1] 瞿秀华[2] 赵晓航[2,3] 

机构地区：[1]南方医科大学,广州510515 [2]中国人民解放军海军总医院,北京100048 [3]中国医学科学院肿瘤研究所分子肿瘤学国家重点实验室,北京100021

出　　处：《生命科学》2012年第3期228-235,共8页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(91029725;30973373);国家重点基础研究发展计划("973"项目)(2011CB-910703)

摘　　要：氧化偶氮甲烷(azoxymethane,AOM)/葡聚糖硫酸钠(dextran sodium sulfate,DSS)小鼠模型是一种在致癌剂AOM和致炎剂DSS协同作用基础上,由炎症性肠病(inflammatory bowel disease,IBD)逐步发展为结直肠癌的炎症相关性癌症的研究模型。AOM/DSS模型能很好地模拟慢性肠道炎症诱发癌症的生理病理过程,近年来被广泛用于炎症相关性癌症形成机制的研究。简要综述AOM/DSS模型与炎症相关性癌症癌变机理的研究进展。The azoxymethane （AOM）/dextran sodium sulfate （DSS） murine model is a kind of inflammationassociated colorectal cancer model, which is based on the combination use of carcinogen AOM with the inflammatory agent DSS and characterized by progressing gradually from inflammatory bowel disease （IBD） to colorectal cancer. Since it can well simulate the physiological and pathological processes of chronic intestinal inflammation-induced cancer, it has been widely utilized to investigate the formation mechanisms of inflammation- associated cancers in recent years. This review briefly summarizes current advances in the AOM/DSS model and its experimental study of the mechanisms of inflammation-associated carcinogenesis.

关 键 词：动物模型 氧化偶氮甲烷/葡聚糖硫酸钠 炎症相关癌症形成 

分 类 号：R-332[医药卫生] R73-3