艾司西酞普兰联合安脑丸治疗脑卒中后抑郁的疗效观察  

作　　者：任莉[1] 张立亮 

机构地区：[1]沈阳市第一人民医院神经内科,110041 [2]辽宁省武警总队本溪市支队卫生队,117000

出　　处：《当代医学》2012年第10期11-12,共2页Contemporary Medicine

摘　　要：目的观察艾司西酞普兰联合安脑丸治疗脑卒中后抑郁的疗效及对神经功能康复的影响。方法将97例急性脑卒中伴抑郁的患者随机分为治疗组(50例)和对照组(47例)。除两组均按各自的脑卒中类型给予抗凝、改善微循环、营养神经、调节血压等常规治疗外,治疗组给予草酸艾司西酞普兰和安脑丸治疗,对照组给予草酸艾司西酞普兰治疗。在治疗前和治疗后第8周分别用"脑卒中患者临床神经功能缺损程度评分标准"和汉密尔顿抑郁量表(HAMD)评定疗效。结果与对照组相比,治疗组HAMD评分和神经功能缺损程度评分的减分率均高于对照组,两组比较显效率具有显著差异(P<0.05)。结论艾司西酞普兰联合安脑丸治疗脑卒中后抑郁及对神经功能康复的影响疗效良好,且不良反应发生率低。Objective To observe the effect of Escitalopram and Annao pill in the treatment of post-stroke depression, and the influence of rehabilitation of neural function.Methods ninety-seven cases of acute stroke patients with depression were randomly divided into treatment groups （n=50） and control groups （n=47）. Besides giving each group anticoagulation, improving microcirculation, trophic nerve and lower blood pressure, Treatment group were given of Escitalopram Oxalate and Annao pill, and control group were given Escitalopram Oxalate only. The outcomes were evaluated by ＂clinical accessing standard of neurological function in stroke＂ and the Hamilton depression scale （HAMD） before treatment and 8 weeks after treatment. Results Compared with the control group, HAMD scores and Nerve function defect score deduction rates in treatment group were higher （P〈0.05）. Conclusion Treatment of Escitalopram Oxalate and Annao pill can effectively improve the poststroke depression, and promote nerve function rehabilitation, and the side effects were low.

关 键 词：脑卒中 抑郁 神经功能康复 艾司西酞普兰 安脑丸 

分 类 号：R749.1[医药卫生—神经病学与精神病学]