帕罗西汀联合小剂量奥氮平治疗创伤性脑损伤伴发精神行为障碍的疗效与安全性  

作　　者：龚昌海[1] 童芳[1] 陈仁德[1] 周华[1] 陈香[1] 

机构地区：[1]攀枝花市第三人民医院心理卫生中心,617061

出　　处：《当代医学》2012年第10期130-131,共2页Contemporary Medicine

摘　　要：目的小剂量奥氮平联合帕罗西汀在脑外伤后伴发精神行为障碍的疗效和安全性。方法对脑外伤后伴有精神行为障碍的72例患者使用奥氮平5mg,每晚,联合帕罗西汀20mg,每早治疗,使用汉密尔顿抑郁量表(HAMD),汉密尔顿焦虑量表(AMMA),阳性与阴性量表(PANSS)和副反应量表(TESS)评定疗效和不良反应。结果精神病阳性症状在第一周即开始明显起效,三、四周完全控制。一般攻击性第三四周明显改善,对阴性症状不明显。焦虑抑郁改善显著,特别是焦虑,不管是精神焦虑或是躯体焦虑,第一周即明显起效,第二周开始就基本控制。副反应少,且较轻微。结论在脑外伤后伴有精神行为障碍者脑损伤治疗同时,用小剂量奥氮平联合帕罗西汀改善精神行为障碍疗效好,安全,无明显药物间相互不良反应。Objective To explore the clinical efficacy and safety of quetiapine in the treatment of traumatic brain injury accompaning mental symptoms and behavior disorder. Methods A total of 72 patients with traumatic brain injury accompaning mental symptoms and behavior disorder took orally olanzapine 5rag qn.and combining with paroxetine20mg qd. Clinical efficacies and adverse reactions were assessed with the HAMD, AMMA, PANSS, TESS. Results The positive symptoms was effective markedly in the 1st week ,it was controlled complete in the 3rd and 4th week. The aggressive behavior was improved markedly in the 3rd and 4th week,the negative symptoms was no improved markedly. The anxiety and depression were improved markedly, especially in the anxiety, it was effective markedly in the 1st week, controlled in the 2nd week. Conclusion olanzapine combining with paroxetine in treatment of traumatic brain injury accompaning mental symptoms and behavior disorder takes effects and has good safety and fewer increase side effects.

关 键 词：奥氮平 帕罗西汀 创伤性脑损伤 精神行为障碍 疗效 安全性 

分 类 号：R749.1[医药卫生—神经病学与精神病学]