毛细管电泳磺丁基-β-环糊精拆分对映体  

Enantiomeric Separation with Sulfobutyl Ether-β-Cyclodextrin as Chiral Additive by Capillary Electrophoresis

作　　者：阮宗琴[1] 陆豪杰[1] 欧庆瑜[1] 

机构地区：[1]中国科学院兰州化学物理研究所,兰州730000

出　　处：《分析化学》2000年第2期168-171,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金;兰州化学物理研究所所长基金

摘　　要：将平均取代度为3.8的负电性磺丁基-β-环糊精手性添加剂应用于毛细管电泳对映体拆分的研究中。考察了背景电解质pH及磺丁基-β-环糊精浓度对手性拆分的影响，应用磺丁基-β-环糊精拆分八对碱性和酸性的药物对映体。Enantiomeric separations of chiral drugs with an anionic chiral resolving agent, sulfobutyl ether β-cyclodextrin(SBE-β-CD) with average substitute degree 3. 8, employed as chilal additive by capillary electrophoresis were achieved. The effects of pH of background electrolyte, the concentration of sulfobutyl ether-β-cyclodextrin on chiral separation were investigated. The enantiomeric separation of six basic and two acidic chiral drugs was accomplished. Sulfobutyl ether-β-cylodextrin was proved to be a good chiral selector having itself electrophretic mobility.

关 键 词：毛细管电泳 Β-环糊精 和性拆分 手性分离 

分 类 号：O657.8[理学—分析化学]