贵州省首例半相合骨髓移植治疗急性白血病报告  

The first haploidentical bone marrow transplantation for acute leukemia in Guizhou Province

作　　者：卢英豪[1] 王季石[1] 孙志强[1] 熊杰[1] 谢润兰[1] 龙正美[1] 

机构地区：[1]贵阳医学院附属医院血液科,550004

出　　处：《贵州医药》2011年第10期876-879,共4页Guizhou Medical Journal

基　　金：国家自然科学基金[81070444];贵州省科技厅基金[2009108];贵州省社会攻关项目基金[黔科通(2011)3012]

摘　　要：目的探讨半相合骨髓移植治疗急性白血病的疗效。方法对1例男性47岁急性髓系白血病M2型患者采用半相合骨髓移植。预处理方案采用改良的BU/CY方案;GVHD的预防采用ATG+CSA+MMF+MTX方案;移植方式采用骨髓加外周血移植。结果移植后19d患者造血功能重建。移植后第30天、90天、180天行STR-DNA检测,为完全供者型嵌合。移植后两个月查血型转为供者血型(A型)。随访1年,目前患者已恢复正常工作,生活质量良好,复查外周血象、骨髓象均正常,已停用抗排异反应的药物及预防感染的药物。结论单倍体异基因骨髓移植是治疗白血病的一种安全、有效的方法,且解决了供者来源困难,值得推广及深入研究。Obieetive To explore the efficacy which acute leukemia with HLA-haploidentical HSCT were treated. Methods A patient of 47 years old male with acute myeloid leukemia （M2） was treated with HLA-haploidentical HSCT. Pretreatment scheme was used the BU/CY as conditioning regimen, the prevention of GVHD was ATG＋ CSA＋ MMF＋ MTX regimens, Mode of transplanta-tion was peripheral blood stem cells plus allogenic bone marrow transplantation. ResullsThe patients acquired hemopoietic reconstruction at day 19 after transplatation. On day 30,90,180, STR signed the completed host chimera, the recipient,s blood type changed from AB to A. The patient was followed up for 1 year. The patient was back to normal with good life quality. The peripheral hemogram and the myelogram showed normal. The drugs for anti-rejection and preventing infection were discontin- ued. Conclusion HLA-haploidentical HSCT is a safe and effective method in the treatment of leukemia. It can resolve the shortage of donors and is worthy to be popularized and in-depth researched.

关 键 词：半相合骨髓移植 急性白血病 预处理 GVHD 

分 类 号：R733.71[医药卫生—肿瘤]