复方甘枣宁预防大鼠非酒精性脂肪肝的实验研究  

Experimental study on preventive effect of Ganzaoning Recipe in rats with non-alcoholic fatty liver

作　　者：张亚妮[1] 汪晨[1] 罗梅宏 

机构地区：[1]上海长海医院中医科,上海200433 [2]上海市中医院,上海200127

出　　处：《中国中西医结合消化杂志》2012年第3期119-122,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家自然科学基金资助项目(30901986)

摘　　要：[目的]研究复方甘枣宁对高脂饮食诱发的大鼠脂肪肝的预防作用。[方法]采用高脂饲料喂饲制作大鼠非酒精性脂肪肝模型,同时以复方甘枣宁灌胃,12周后检测血清中总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)水平,并作病理组织学观察,同时称体重、肝脏重,计算肝指数。[结果]复方甘枣宁明显减轻肝组织内脂肪变性,降低血清TC与AST水平。[结论]复方甘枣宁对高脂饮食诱发的大鼠非酒精性脂肪肝具有一定的预防作用。[Objective]To study the preventive effect of Ganzaoning recipe in non-alcoholic fatty liver （NAFL） rat model. [Methods]NAFL rat models were induced by oral administration of high-fat diet, and then administered with Ganzaoning. Models were sacrificed at the end of 12 weeks to calculate the body weight and liver index. The serum levels of total cholesterol（TC）, triglyceride（TG）, alanine aminotransferase（ALT）, and aspartate aminotransferase（AST）were measured. Fatty infiltration in hepatic lobules were also observed by pathology. [Results]A significant reduction was observed in the hepatic steatosis. Compared with model group, the levels of serum TC and AST of Ganzaoning group decreased obviously （P〈0.05）. [Conclusion]Ganzaoning has preventative effect on NAFL rats induced by high fat diet.

关 键 词：甘枣宁 复方 脂肪肝 非酒精性 

分 类 号：R575.5[医药卫生—消化系统]