Comparison of the effects of cholecalciferol and calcitriol on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency  

作　　者：Hao ZHANG Qi-ren HUANG Jie-mei GU Wei-wei HU Yu-juan LIU Yun-qiu HU Zhen-lin ZHANG 

机构地区：[1]Metabolic Bone Disease and Genetic Research Unit,Department of Osteoporosis and Bone Diseases,Shanghai Jiao Tong University,Affiliated Sixth People's Hospital,Shanghai 200233,China

出　　处：《Acta Pharmacologica Sinica》2012年第4期490-495,共6页中国药理学报（英文版）

基　　金：Acknowledgements This study was supported by the National Natural Science Foundation of China （NSFC） （No 30800387, 30771019, 81070692, 81170803）, Academic Leaders in Health Sciences in Shanghai （XBR2011014）, STCSM10DZ1950100, Science and Technology commission of Shanghai municipality （11ZR1427300） and Shanghai Rising Star Project （No 11QA1404900）.

摘　　要：Aim： To compare the effects of cholecalciferol （800 IU/d） and calcitriol （0.25 pg/d） on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency. Methods： One hundred Chinese postmenopausal women aged 63.8±7.0 years and with serum 25-hydroxyvitamin D [25（OH）D] concentration 〈30 ng/mL were recruited. The subjects were divided into 2 groups based on the age and serum 25（OH）D concentration： 50 subjects （group A） received cholecalciferol （800 IU/d）, and 50 subjects （group B） received calcitriol （0.25 pg/d） for 3 months. In addition, all the subjects received Caltrate D （calcium plus 125 IU cholecalciferol） daily in the form of one pill. The markers of calcium metabolism and bone turnover, including the serum levels of calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone, 25（OH）D and β-CrossLaps of type I collagen containing cross-linked C-telopeptide （β-CTX）, were measured before and after the intervention. Results： After the 3-month intervention, the serum 25（OH）D concentration in group A was significantly increased from 16.01±5.0 to 20.02±4.5 ng/mL, while that in group B had no significant change. The serum calcium levels in both the groups were significantly increased （group A： from 2.36±0.1 to 2.45±0.1 mmol/L; group B： from 2.36±0.1 to 2.44±0.1 mmol/L）. The levels of serum intact parathyroid hormone in both the groups were significantly decreased （group A： from 48.56±12.8 to 39.59±12.6 pg/mL; group B： from 53.67±20.0 to 40.32±15.4 pg/mL）. The serum levels of ^-CTX in both the groups were also significantly decreased （group A： from 373.93_＋135.3 to 325.04±149.0 ng/L; group B： from 431.00±137.1 to 371.74±185.0 ng/L）. Conclusion： We concluded that both cholecalciferol （800 IU/d） and calcitriol （0.25 μg/d） plus Caltrate D modifies the serum calcium and bone turnover markers in Chinese postmenopausal women with vitamin D insufficiency. In addition, choAim： To compare the effects of cholecalciferol （800 IU/d） and calcitriol （0.25 pg/d） on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency. Methods： One hundred Chinese postmenopausal women aged 63.8±7.0 years and with serum 25-hydroxyvitamin D [25（OH）D] concentration 〈30 ng/mL were recruited. The subjects were divided into 2 groups based on the age and serum 25（OH）D concentration： 50 subjects （group A） received cholecalciferol （800 IU/d）, and 50 subjects （group B） received calcitriol （0.25 pg/d） for 3 months. In addition, all the subjects received Caltrate D （calcium plus 125 IU cholecalciferol） daily in the form of one pill. The markers of calcium metabolism and bone turnover, including the serum levels of calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone, 25（OH）D and β-CrossLaps of type I collagen containing cross-linked C-telopeptide （β-CTX）, were measured before and after the intervention. Results： After the 3-month intervention, the serum 25（OH）D concentration in group A was significantly increased from 16.01±5.0 to 20.02±4.5 ng/mL, while that in group B had no significant change. The serum calcium levels in both the groups were significantly increased （group A： from 2.36±0.1 to 2.45±0.1 mmol/L; group B： from 2.36±0.1 to 2.44±0.1 mmol/L）. The levels of serum intact parathyroid hormone in both the groups were significantly decreased （group A： from 48.56±12.8 to 39.59±12.6 pg/mL; group B： from 53.67±20.0 to 40.32±15.4 pg/mL）. The serum levels of ^-CTX in both the groups were also significantly decreased （group A： from 373.93_＋135.3 to 325.04±149.0 ng/L; group B： from 431.00±137.1 to 371.74±185.0 ng/L）. Conclusion： We concluded that both cholecalciferol （800 IU/d） and calcitriol （0.25 μg/d） plus Caltrate D modifies the serum calcium and bone turnover markers in Chinese postmenopausal women with vitamin D insufficiency. In addition, cho

关 键 词：CHOLECALCIFEROL CALCITRIOL calcium metabolism bone turnover parathyroid hormone 25-hydroxyvitamin D β-CrossLaps oftype I collagen containing cross-linked C-telopeptide （β-CTX） postmenopausal women 

分 类 号：S831.5[农业科学—畜牧学] S966.22[农业科学—畜牧兽医]