大剂量宁红欣冲击治疗恶性肿瘤贫血的疗效观察  

Effects of Large Doses of Recombinant Human Erythropoietin Pulse Treatment on Anemia Associated with Cancer Therapy

作　　者：费立升[1] 

机构地区：[1]山东省日照市人民医院办公室,276826

出　　处：《中华全科医学》2012年第4期550-550,662,共2页Chinese Journal of General Practice

摘　　要：目的观察大剂量宁红欣冲击治疗恶性肿瘤贫血的疗效及不良反应。方法将94例恶性肿瘤贫血患者随机分入试验组或对照组,前者接受大剂量宁红欣冲击治疗,用法为第1天、第3天给予宁红欣4万U皮下注射,在第5,7,9,11,13,15,17天给予宁红欣2万U皮下注射;后者接受常规剂量宁红欣治疗6周。对患者的有效率、血红蛋白值、输血需求率、卡氏评分及药物不良反应进行观察。结果试验组患者治疗2周后血红蛋白值明显升高,对照组患者治疗4周后血红蛋白值明显升高;试验组4周、6周血红蛋白值均高于对照组(P<0.05);试验组2周、4周、6周有效率为43.5%、63.0%、83.3%,高于对照组的17.8%、31.1%、53.3%(P<0.01);两组患者卡氏评分、输血需求率及不良反应差异无统计学意义(P>0.05)。结论大剂量宁红欣冲击治疗恶性肿瘤贫血疗效确切,优于常规剂量法,不良反应相似。Objective To observe the clinical effects and adverse reactions of large doses of recombinant human erythropoie tin pulse treatment on anemia associated with cancer therapy. Methods Ninety four patients with anemia associated with cancer therapy were randomly divided into experimental group and control group. Patients in experimental group were treated with large doses of erythropoietin（40 000 units on dt and d3 ,20 000 units on ds ,d7 ,d9 ,d1, ,d13 ,d15 and d17 ） ,while the control group with conventional doses of erythropoietin. The curative efficient, hemoglobin value, blood transfusion rate, Karnofsky performance status （KPS） score and adverse reaction were observed. Results After 2 weeks, hemoglobin values of the experimental group were sig nificantly increased ,while that of the control group were increased after 4 weeks. Hemoglobin values of 4,6 weeks of the experi mental group were higher than that of control group （ P 〈 0.05 ）. Effective rates of 2,4,6 weeks in experimental group were 43.5% ,63.0% and 83.3% ,respectively,higher than 17.8% ,31.1% and 53.3% in the control group（P 〈 0.01 ）. There was no difference in KPS score, blood transfusion rate and adverse reaction between the two groups （ P 〉 0.05 ）. Conclusion The im pact of large doses of recombinant human erythropoietin therapy is superior to the conventionaldose methods for anemia associat ed with cancer, without more side reactions.

关 键 词：重组人红细胞生成素 恶性肿瘤 贫血 

分 类 号：R730.54[医药卫生—肿瘤]