注射用尤瑞克林对脑梗死患者神经功能及血清基质金属蛋白酶9的影响  

Effect of urinary kallidinogenase for injection on neurological function and serum matrix metailoproteinase 9 in patients with acute cerebral infarction

作　　者：宋贵军[1] 

机构地区：[1]大连医科大学附属第二医院神经内科,116027

出　　处：《中国医师进修杂志》2012年第9期10-12,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨注射用尤瑞克林对脑梗死患者神经功能及血清基质金属蛋白酶9（MMP－9）的影响。方法90例急性脑梗死患者按随机数字表法分为观察组和对照组，每组45例，对照组采用常规治疗，观察组在常规治疗基础上加用注射用尤瑞克林，0．15PNAU／d，治疗10d。分别采用国立卫生研究院卒中量表（NIHSS）及Barthel指数（BI）量表评价患者神经功能缺损程度和日常生活活动能力，应用酶联免疫吸附试验法检测血清MMP-9水平。并比较两组的疗效及治疗前后NIHSS评分、BI评分、血清MMP-9水平的变化。结果观察组总有效率[88．9％（40145）]显著高于对照组[71．1％（32／45）]，差异有统计学意义（P〈0．05）。两组治疗后3个月NIHSS评分明显降低，BI评分明显升高，与治疗前比较差异有统计学意义（P〈0．05）。观察组治疗后3个月NIHSS评分[（6．56±0．74）分]显著低于同期对照组[（9．06±0．87）分]，BI评分[（79．98±7．32）分]显著高于同期对照组[（72．57±6．95）分]，差异均有统计学意义（P〈0．05）。两组治疗后10d血清MMP．9水平均显著降低，与治疗前比较差异有统计学意义（P〈0．05）。观察组治疗后10d血清MMP-9水平[（187．58±14．52）ng／L]显著低于同期对照组[（238．89±17．48）ng／L]，差异有统计学意义（P〈0．05）。结论注射用尤瑞克林可以显著改善脑梗死患者神经功能，明显降低血清MMP－9水平，有较好的疗效，具有很高的临床应用价值。Objective To investigate the effect of urinary kallidinogenase for injection on neurological function and serum matrix metalloproteinase 9 （MMP-9） in patients with cerebral infarction. Methods Ninety patients of acute cerebral infarction were divided into observation group and control group by randomdigits table with 45 cases each. The control group was treated with conventional therapy. The observation group was treated with conventional therapy and additional urinary kallidinogenase for injection treatment, 0.15 PNA U/day, for 10 days. National institutes of health stroke scale （NIHSS） score and Barthel index（BI） score were used to evaluate the neurological impairment and the abilities of activities of daily living. The serum MMP-9 levels was tested by enzyme linked immunosorbent assay. The treatment outcome, NIHSS score, BI score and serum MMP-9 level were compared. Results The total effective rate in observationgroup [88.9%（40/45）] was higher than that in control group [71.1%（32/45）], and there was significant difference （P 〈 0.05）. NIHSS score after 3 months treatment was decreased and BI score was increased compared with before treatment in two groups, and there were significant differences（P 〈 0.05 ）. NIHSS scoreafter 3 months treatment in observation group [ （6.56 ±0.74） scores] was lower than that in control group[ （9.06 ±0.87 ） scores ], and there was significant difference （P 〈 0.05 ）. BI score after 3 months treatment in observation group [ （79.98 ± 7.32） scores ] was higher than that in control group [ （72.57 ± 6.95） scores ], and there was significant difference （P 〈 0.05 ）. Compared with before treatment, the serum MMP-9 levelafter 10 days treatment was significantly decreased in two groups （P 〈 0.05 ）. The serum MMP-9 level after 10 days treatment in observation group[ （ 187.58 ± 14.52） ng/L] was lower than that in control group[ （238.89 ±17.48） ng/L] with significant difference （P 〈 0.05 ）. Conclusions Urinary k

关 键 词：基质金属蛋白酶9 脑梗塞 尤瑞克林 

分 类 号：R743.3[医药卫生—神经病学与精神病学]