壳聚糖卵磷脂对轻度认知障碍患者语义理解事件相关电位N400的影响  

The impact of Chitosan Lecithin on the mild cognitive impairment patients＇ semantic understanding by e- vent-related potential N400

作　　者：杨海英[1] 孟庆慧[1] 许桂春[1] 李秀艳[1] 张瑜[1] 孙延超[1] 

机构地区：[1]潍坊医学院护理学院（新校区）,潍坊261053

出　　处：《中华行为医学与脑科学杂志》2012年第3期203-205,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：山东省自然科学基金资助项目（Y2008C125）;山东省教育厅科技计划项目（J08LH67）

摘　　要：目的探讨壳聚糖卯磷脂对轻度认知障碍（MCI）患者语义理解N400的影响。方法从潍坊某老年院500名老年人中用简易智能状态量表检查（MMSE）筛选出了32名MCI患者，按照随机数字表分为观察组（n=16）和对照组（n=16），观察组给予壳聚糖卯磷脂，对照组给予等剂量的安慰剂，干预时间为2个月，干预前后应用语义违例实验要求被试者进行语义判定，同时记录32名MCI患者干预前后的脑电图并分析数据。结果1）2组均产生较明显的额、中央、顶区分布的特异性成分N400；2）观察组反应时及正确率[分别为（965．13±178．07）ms，（92．56±2．36）％]，对照组反应时间及正确率[分别为（1126．13±252．77）ms，（85．28±5．73）％]，差异有统计学意义（P〈0．05）；3）观察组N400潜伏期为[（425．28±47．26）1／IS]，缩短于对照组[（456．19±37．75）ms]，差异有统计学意义（F=6．01，P〈0．05）；观察组N400波幅为[（4．79±2．18）μV]，高于对照组[（3．59±1．33）μV]，差异有统计学意义（F=5．96，P〈0．05）。结论壳聚糖卵磷脂能够使MCI患者的N400潜伏期缩短，波幅增高，对MCI患者语义理解的恢复有一定的帮助。Objective To study the impact of Chitosan Lecithin on the mild cognitive impairment （MCI） patients＇ semantic understanding by event-related potential N400. Methods 32 patients with MCI were screened from 500 elder people aged Court in Weifang by mini-mental state examination （ MMSE ） scale, and were divided into two groups：the observation group （ n= 16） and the control group （ n= 16） by the table of random numbers. The observation group were given Chitosan Lecithin while the control group were given an equal dose of placebo. The intervention time was 2 months. The subjects were asked to conduct semantic judgement by semantic violation experiment. Thirty-two channels electroencephalogram（EEG） was recorded by Neuroacan Nuamps Systerm and ana- lyzed data. Results 1 ） Specific component N400 was found in both groups ,which was distributed at the frontal, central and parietal regions. 2） The observation group reaction time and correct rate were respectively （965.13 ±178.07） ms and （92.56 ± 2.36 ）% , while the control group were respectively （1126. 13 ± 252.77 ）ms and （ 85.28 ± 5.73 ） %, with significant difference （P 〈 0.05 ）. 3 ） Compared with N400 in control group, N400 latency was shorter （ （425.28 ± 47.26） ms vs （456.19 ± 37.75 ） ms, F = 6.01, P 〈 0.05 ） and amplitude was higher （ （4.79 ± 2.18 ） μV vs （3.59± 1.33 ） μV, F = 5.96, P 〈 0.05 ）. Conclusion Chitosan lecithin has the effect of N400 latency and amplitude,it may be helpful for the patients of MCI in semantic understanding.

关 键 词：壳聚糖卵磷脂 轻度认知障碍 事件相关电位 N400 

分 类 号：R741.044[医药卫生—神经病学与精神病学]