正十二烷基-L-羟基脯氨酸手性配位萃取拆分外消旋苯丙氨酸  

Resolution of D,L-Phenylalaine by Chiral Coordination Extraction with n-Dodecyl-L-hydroxyproline

作　　者：崔玉[1] 孙国新[1] 田晓强 夏光明[1] 公佩欣[1] 

机构地区：[1]济南大学化学化工学院,济南2500221 [2]美国应用生物系统公司,济南250014

出　　处：《无机化学学报》2012年第4期686-690,共5页Chinese Journal of Inorganic Chemistry

基　　金：山东省自然科学基金(No.ZR2009BM046);山东省重点学科基金(No.XTD0704)资助项目

摘　　要：本文合成新手性配体正十二烷基-L-羟基脯氨酸,研究手性配体正十二烷基-L-羟基脯氨酸与Cu髤配位萃取拆分苯丙氨酸的性能和机理,考察起始氨基酸浓度、配位铜离子浓度、萃取剂浓度、溶液pH值及温度等因素分别对D-和L-苯丙氨酸萃取性能的影响,萃取剂对D-苯丙氨酸的识别能力强。利用多种手段对萃合物的组成进行表征,推测萃合物的结构为1∶1∶1型三元配合物。对比发现:该萃取剂配位萃取拆分苯丙氨酸性能优于正辛基-L-羟基脯氨酸,空间位阻效应反而对拆分有利。The novel chiral extractant n-dodecyl-L-hydroxyproline was synthesized. The resolution of D,L- phenylalaine by chiral coordination extraction with n-Dodecyl-L-Hydroxyproline and Cu（lI） was studied. The effect of the initial aqueous phenylalanine concentration, concentrations of copper ion and extractant, pH and extraction temperature on the extraction distribution of D,L-phenylalaine were investigated. The extractant showed better affinity for D-phenylalaine. The extracted species were characterized and the stoichiometry was suggested to be 1： 1：1 to form a ternary complex. The results showed that the resolution efficiency with n-Dodecyl-L-Hydroxyproline is better than that with n-octyl-L-Hydroxyproline, which indicated that n-dodecyl with its bigger steric effect favors the separation of D,L-phenylalanine compared with the smaller n-octyl group.

关 键 词：正十二烷基.L-羟基脯氨酸 手性配体 萃取拆分 D/L-苯丙氨酸 

分 类 号：TQ028.32[化学工程]