人类白细胞抗原I类抗原转运相关蛋白1在胶质瘤组织中的表达及其与抗原转运相关蛋白-2的关系  

Expression of human ieuocyte antigen I antigen and antigen processing machinery components in glioma tissues and their correlation with transporter associated with antigen processing 2

作　　者：李方成[1] 张善义[1] 李军亮[1] 许新科[1] 郑眉光[1] 温铖彩[1] 余舰[1] 翁胤仑[1] 

机构地区：[1]中山大学孙逸仙纪念医院神经外科,广州510120

出　　处：《中华实验外科杂志》2012年第4期682-684,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目（81072081）

摘　　要：目的观察胶质瘤患者肿瘤组织中人类白细胞抗原（HLA）I类抗原及抗原转运相关蛋白（TAP）1、TAP2的表达，探讨其与肿瘤病理级别的关系。方法收集41例经病理确诊的胶质瘤患者肿瘤组织标本，通过免疫组织化学的方法，观察不同病理级别肿瘤标本中HLAI类抗原及抗原加工递呈（APM）分子的表达水平，探讨HLAI类抗原和APM分子表达与胶质瘤患者病理级别之间的关系。结果HLAI类抗原丢失在各级别胶质瘤组织中分别为11％（1／9）、25％（3／12）、30％（3／10）及40％（4／10）。TAPl和TAP2蛋白水平均与胶质瘤分级明显相关（P〈0．05），表达水平随胶质瘤分级增加表达下降。此外，TAP1表达水平与TAP2明显相关（P〈0．05）。结论胶质瘤组织中HLAI抗原和部分APM分子蛋白水平，随胶质瘤级别增加而降低；这可能是导致部分T细胞免疫治疗失败的原因之一。Objective To observe the expression of human leukocyte antigen I （ HLA I） and anti- gen processing machinery （APM） components, and their correlation with pathological grading. Methods Forty-one tumor sections from forty-one glioma patients were examined by using immunohistochemistry. The expression of HLA I antigen and APM components was detected, and their correlation with the pathological grading was analyzed. Results Frequency of HLA I antigen loss in dedicated groups was 11%, 25% , 30% and 40% , respectively. There was a positive correlation between the expression levels of transporter associated with antigen processing （TAP） 1 and TAP2 with glioma pathological grading （P 〈 0.05）. Additionally, there was a positive correlation between TAP1 and TAP2 level （P 〈 0.05）. Conclusion The level of HLA I antigen and most of APM components expression is decreased with the increase in tumor patho-logical grade, which may explain the phenomenon that glioma cells frequently escape from immunological surveillance or immunotherapy.

关 键 词：胶质瘤 抗原加工 病理分级 

分 类 号：R739.41[医药卫生—肿瘤]