回顾分析不同年代首次住院精神分裂症病人的药物使用  

Retrospective Analysis of Contrasting the usage of psychotic drugs for schizophrenic inpatient in different years

作　　者：李文飞[1] 王克永[1] 邹延峰[2] 王克明[1] 吴庆[1] 白伟[1] 

机构地区：[1]安徽省精神卫生中心,合肥230022 [2]安徽医科大学公共卫生学院,合肥230022

出　　处：《安徽卫生职业技术学院学报》2012年第1期84-85,83,共3页Journal of Anhui Health Vocational & Technical College

摘　　要：目的:探讨不同年代住院精神分裂症的就诊及治疗状况。方法:抽取1988年2月1日～5月30日首次住院的精神分裂症患者患者设为A组,共159例;1998年的同期住院患者设为B组,共159例;2008年同期的住院患者设为C组,共167例。统计入组患者的一般资料及药物治疗状况并进行回顾对比分析。结果:三组患者在就诊年龄方面无显著性差异(P>0.05),C组在受教育年限、就诊时间方面与对照组有显著性差异(P<0.01);而住院时间方面B组和C组与A组均有显著性差异(P<0.01),但两研究组之间则无显著性差异。抗精神病药物氯氮平、利培酮、喹硫平、阿立哌唑、氯丙嗪的使用率与对照组相比均有显著性差异(P<0.01);合并使用氯氮平、利培酮、舒必利、氯丙嗪、碳酸锂、丙戊酸钠以及氯硝西泮均有显著性差异(P<0.01);C组中单用氯氮平组较B组有显著性差异(P<0.05)。结论:首发精神分裂症患者住院时间有明显缩短趋势,受教育年限在逐渐提高;新型抗精神病药使用率有明显增加趋势。Objective：To study the status of the schizophrenic inpatients＇ seeking medical advice and treatment in different years. Method： 159 schizophrenics first hospitalized from February 1 to May 30,1988 were assigned to group A,159 ones in the corresponding period in 1998 to group B and 167 ones in 2008 to group C. General infor- mation, and medication status were added up and contrastively and retrospectively analyzed. Results：Tilese were no differences in first- hospitalzation age among three groups （P 〉 0.05 ） ,were significant differences in firsf- hospi- talzation course of disease,education time -limit and length of stay（P 〈0.05 or 0.01 ） ;both education time -limit and course of disease were significantly longer in group C than in A （ P 〈 0.05 ）, length of stay was significantly shor- ter in group B and C than in A（ P 〈 0.01 ）. Utilizations of antipsychotics clozapine has significant difference com- pared with control group （ P 〈 0.01 ）. and that of risperidone, quetiapine, aripiprazole, chlorpromazine, lithium car- bonate ,valpromide clonazepam also. Combined with clozapine, risperidone, sulpiride and chlorpromazine group has marked difference compared with control group（P 〈0.01 ）. The urique utilizations of clozapines＇ group in group 3 has significant difference compared with group 2 （P 〈 0.05 ）. Conclusions：The patients suffering schizophrenia for the first time have obviously shortened trend in hospitalization -time and increased gradually in educated -period. Utlizations of novel antipsychotics have obvious increasing tendency.

关 键 词：精神分裂症 精神药物 住院病人 治疗 

分 类 号：R749.3[医药卫生—神经病学与精神病学]