大鼠多发性关节炎早期颞下颌关节的组织病理学研究  

Histopathological study of temporomandibular joint in early stage of polyarthritis rats

作　　者：王海鹰 王丛妙[2] 王德文[3] 王东胜 赵彦萍 

机构地区：[1]北京医科大学口腔医学院病理科 [2]北京军区总医院风湿科 [3]军事医学科学院二所 [4]解放军总医院口腔科,北京100853

出　　处：《中华口腔医学杂志》2000年第2期123-125,I012,共4页Chinese Journal of Stomatology

摘　　要：目的　观察大鼠多发性关节炎 (polyarthritis,PA)早期颞下颌关节 (temporomandibularjoint,TMJ)的组织病理学变化 ,为研究类风湿关节炎 (rheumatoidarthritis,RA)早期对TMJ的影响提供实验依据。方法　用福氏完全佐剂建立大鼠PA模型 ,观察其踝关节和TMJ的组织病理学变化。结果　①大鼠PA时 ,踝关节体积显著增大 ,关节指数明显增高 ;踝关节滑膜组织增生 ,炎性细胞浸润 ,关节软骨及骨质受侵蚀 ,关节腔炎性渗出明显。②大鼠PA时 ,双侧TMJ均可见滑膜细胞显著增生 ;髁突表层胶元纤维松解 ,软骨细胞变性 ;关节腔可见蛋白渗出 ,细胞脱落 ,局部呈纤维性粘连。结论　大鼠PA早期双侧TMJ即有明显的炎性病变。Objective To furnish an experimental basis of the early effects of rheumatoid arthritis (RA) on the temporomandibular joint (TMJ) by observing the histopathological changes of TMJ in the early stage of polyarthritis (PA) rats.Methods The animal model of PA was established by injecting Freund's complete adjuvant (FCA) into rats. The histopathological changes of the rats' ankle joint and TMJ were studied. Results (1)The paw volume and the articular index of PA rats increased significantly, and symptoms of pronounced inflammation were present in the ankle joint specimens, which included proliferation of the synovium, infiltration with inflammatory cells, erosion into the articular cartilage and bone, and inflammatory exudation into the articular cavities.(2)The histopathology of TMJ of PA rats showed pronounced proliferation of the synovium cells, some lytic collagenous fibers and degenerative chondrocytes in the condyles, and exudated protein and desquamating cells in the articular cavities with some fibrinous adhesions. Conclusion Pronounced inflammation occurs in bilateral TMJ in early stage of PA rats. The examination, protection and treatment of TMJ for RA patients should be taken into account in the early stage.

关 键 词：多发性关节炎 颞下颌关节 组织病理学 TMJ 

分 类 号：R780.2[医药卫生—口腔医学]