论中药化学发展近况  

On development of Chinese medicinal chemistry

作　　者：石任兵[1] 姜艳艳[2] 王忠[1] 王永炎[2] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]中国中医科学院临床基础医学研究所

出　　处：《北京中医药大学学报》2012年第3期153-159,共7页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家重大新药创制项目(No.2009ZX09502-006);十二五国家科技支撑计划项目(No.2012BAI29B06);国家自然科学基金资助项目(No.81102776);北京中医药大学创新团队项目(No.2011-CXTD-12);北京中医药大学研究基地建设项目(No.2011-JDJS-13)

摘　　要：随着现代中医药的发展,中药化学作为中医药科研体系重要组成部分,也随之发生了一定变化。中药化学研究涉及3个方面,即以阐明中药自然化学属性和引擎创新药物为目的的中药自然化学,以提升药物创新水平和中药质量控制水平、阐明炮制原理为目的的中药制备化学,以及以阐明药物类药有效物质基础、药物类药动态属性与协同作用特性以及药物动态效应属性及其协同作用特性为目的的中药药物化学。基于前期坚实的研究基础,中药化学的发展应以有效物质基础为核心,融合多学科,着力于开展系统网络药学研究,以全面阐明中药科学内涵,提升中药质量,实现中药质量安全、有效、可控,更好地为人类健康服务。Chinese medicinal chemistry,as an important part of TCM scientific system,has some changes with the development of modern Chinese medicine.The research of Chinese medicinal chemistry involves three aspects,including nature chemistry of Chinese medicinal aiming at illustrating nature chemistry properties of Chinese medicinal and guiding new medicinal development,preparative chemistry of Chinese medicinal aiming at promoting levels of innovation and quality control and illustrating processing principle of Chinese medicinal,and pharmaceutical chemistry of Chinese medicinal aiming at drug-like effective substances,drug-like dynamic property and synergy feature.On the solid foundation of previous study,the effective substances should be taken as core,multiple disciplines should be integrated and study of system network pharmacy should be conducted in the development of Chinese medicinal chemistry.The purpose is to elucidate the scientific connotation and improve the quality of Chinese medicinal,and realize the safe,effective and quality controllable of Chinese medicinal to serve for human health well.

关 键 词：中药化学 内涵 中药自然化学 中药制备化学 中药药物化学 系统网络药学 

分 类 号：R229[医药卫生—中医基础理论]