地佐辛和吗啡用于乳腺癌根治术后静脉镇痛的效果比较  

A comparative study on the effects of intravenous analgesia with dezocine and morphine in patients with radical mastectomy of breast cancer

作　　者：王连叶[1] 阳兴[1] 王远胜[1] 

机构地区：[1]广东省江门市中心医院麻醉科,广东江门529070

出　　处：《实用临床医药杂志》2012年第5期78-79,84,共3页Journal of Clinical Medicine in Practice

摘　　要：目的观察地佐辛用于乳腺癌根治术后的静脉镇痛效果。方法选择60例拟全麻下行乳腺癌根治手术的患者,ASAⅠ、Ⅱ级,随机分为吗啡组(M组)和地佐辛组(D组),每组30例。术毕开始术后镇痛,持续48 h。分别于麻醉前、术毕及术后1、3、24 h采血,应用放射免疫分析法检测血清β-内啡肽(β-EP)。结果两组患者镇痛评分(VAS)、β-EP水平差异均无统计学意义(P>0.05)。结论吗啡和地佐辛均可有效抑制术后应激反应,镇痛效果确切,适合用于术后镇痛。Objective To observe the effects of intravenous analgesia with dezocine and morphine in patients with radical mastectomy of breast cancer.Methods A total of 60 patients undergoing radical mastectomy of breast cancer（ASAⅠ-Ⅱ） were recruited and divided into morphine group（group M,n=30） and dezocine group（group D,n=30）.Patient controlled intravenous analgesia（PICA） lasted for 48 h.Peripheral venous blood was drawn before induction and at 1,3,24 h after operation.Serum levels of β-EP were measured with radioimmunoassay.Results There was no significant statistical significance among the two groups in visual analog scale（VAS） and the serum levels of β-EP（P0.05）.Conclusion Morphine and dezocine can inhibit the stress response and analgesia effectively.

关 键 词：自控静脉镇痛 Β-内啡肽 地佐辛 吗啡 

分 类 号：R737.9[医药卫生—肿瘤]