ERK2在胃黏膜病变中的表达及其与Hp感染的关系  

The Relationship between Extracellular Regulated Protein Kinases 2 Expression and Helicobacter Pylori Infection in Gastric Cancer and Precancerous Lesion

作　　者：雷琳[1] 黄亚平[1] 朱庆茹[1] 江霞[1] 

机构地区：[1]华中科技大学附属襄樊中心医院呼吸内科,441021

出　　处：《实用癌症杂志》2012年第2期144-146,共3页The Practical Journal of Cancer

摘　　要：目的探讨胃癌前病变及胃癌组织中细胞外调节蛋白激酶2(extracellular regulated protein kinases 2,ERK2)表达与幽门螺旋杆菌(helicobacter pylori,Hp)感染的相关性,及Hp感染与胃癌发生的关系。方法收集慢性浅表性胃炎(chronic superficial gastritis,CSG)、慢性萎缩性胃炎伴中重度肠上皮化生(intestinal metaplasia,IM)、慢性萎缩性胃炎伴中重度不典型增生(dysplasia,Dys)各30例及胃癌(gastric cancer,GC)40例,采用SP免疫组化法,检测4组中ERK2蛋白的表达。结果 CSG、IM、Dys、GC组织中,Hp感染患者胃黏膜组织中ERK2表达水平高于无Hp感染患者(P<0.05)。结论 Hp感染可能通过上调ERK2表达水平,从而在胃癌发生、发展过程中发挥重要作用。Objective To explore the relationship between the extracellular regulated protein kinases 2 and Helicobacter pylori（Hp） infection in the pathogenesis of gastric cancel.Methods The expression of ERK2 was determined by immunohistochemical method in 130 gastric specimens including 30 cases of chronic superficial gastritis（CSG）,30 cases of intestinal metaplasia（IM）,30 cases of dysplasia（Dys） and 40 cases of gastric carcinomas（GC）.Results The expression level of ERK2 was significantly higher in the tissues from patients with Hp infection than those without Hp infection in patients with CSG,IM,Dys,GC（P0.05）.Conclusion The expression of ERK2 in Hp positive group was significantly higher than that in Hp negative group.

关 键 词：细胞外调节蛋白激酶2 幽门螺杆菌 胃癌 表达 

分 类 号：R735.2[医药卫生—肿瘤]