高糖条件下高胰岛素水平对细胞内脂质平衡的影响  

The Effect of High Level of Insulin on the Cellular Lipid Balance in Hyperglycemia Condition

作　　者：田玥[1] 廖端芳[1] 谢志忠[1] 

机构地区：[1]南华大学药物药理研究所,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2012年第4期371-374,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(30971170);湖南省高校创新平台开放基金项目(09K073)资助

摘　　要：糖尿病是一种因体内胰岛素绝对不足(Ⅰ型糖尿病)或者相对不足(Ⅱ型糖尿病)而导致的代谢综合征,高血糖是其主要特征之一。现阶段糖尿病的最佳治疗方案仍是胰岛素治疗,但考虑到糖尿病常常并发动脉粥样硬化,且高胰岛素水平对动脉粥样硬化的作用仍然存在着争议,因此阐明高糖条件下,高胰岛素水平对细胞内脂质平衡的影响对糖尿病动脉粥样硬化的治疗有着重要的意义。Diabetes which is due to absolutely lack of insulin （Type I diabetes） or just relatively lack of insulin （Type I1 diabetes） in vivo is a metabolic syndrome, and one of its main features is hyperglycemia. Now the optimized treatment of diabetes is insulin therapy, but the role of high levels of insulin on atherosclerosis remains controversial because diabetes were often complicated by atherosclerosis. Therefore, it is of importance in diabetic atherosclerosis therapy to illustrate the effect of high level of insulin on the cellular lipid balance in hyperglycemia condition.

关 键 词：糖尿病 动脉粥样硬化 脂质平衡 

分 类 号：R363[医药卫生—病理学]