131例非小细胞肺癌患者术后生存分析  

Survival analysis for 131 patients with non-small cell lung cancer after resection

作　　者：梁伟军[1] 胡成平[1] 宋敏[1] 顾其华[1] 陈红梅[1] 

机构地区：[1]中南大学湘雅医院呼吸内科,长沙410008

出　　处：《中国医师进修杂志》2012年第10期20-22,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨非小细胞肺癌（NSCLC）患者术后生存影响因素。方法回顾性分析131例NSCLC患者的临床资料和生存情况，根据治疗方法不同分为两组，化疗组86例（均为第三代化疗药物加铂类方案化疗2个周期以上），未化疗组45例（均因患者意愿未行任何方案化疗）。用Kaplan．Meier法进行生存分析，用Cox比例风险回归模型进行多因素生存分析。结果鳞癌76例，支气管肺泡癌8例，腺癌35例，腺鳞癌12例，中位生存期分别为60、54、34、24个月，差异有统计学意义（P〈0．05）；IB期化疗组26例与未化疗组17例中位生存期分别为75、76个月，差异无统计学意义（P〉0．05）；多因素分析表明肿块大小、T分期、N分期和化疗情况为影响生存期的独立因素（P值分别为0．080、0．002、0．000、0．029）。结论鳞癌、支气管肺泡癌手术预后相对较好；IB期手术患者术后含铂类方案化疗不能延长生存期；肿块大小、T分期、N分期、化疗情况是NSCLC手术患者的独立预后因素。Objective To investigate the prognostic factors of non-small cell lung cancer （NSCLC） after resection. Methods Clinical data of 131 NSCLC patients who underwent resection were reviewed and divided into chemotherapy group （86 cases） and non-chemotherapy group （45 cases） according to the treatment method. Survival rate was calculated by Kaplan-Meier method. The prognosis was analyzed by Cox proportional hazards model. Results The median survival time （MST） of squamous cell carcinoma （76 cases ）, bronchial alveolar cell carcinoma（ 8 cases ）, adenocarcinoma（35 cases ）, adenosquamous carcinoma （ 12 cases） was 60,54,34,24 months respectively （P 〈 0.05 ）. For the patients of stage I B, the MST of chemotherapy group and non-chemotherapy group Was 75 and 76 months respectively（P 〉 0.05 ）. Multivariate analysis showed that tumor size, T stage, N stage, chemotherapy were independent prognostic factors （P = 0.080, 0.002, 0.000, 0.029）. Conclusions Squamous cell carcinoma and bronchial alveolar cell carcinoma have better prognosis than adenocarcinoma, adenosquamous carcinoma. For the patients of stage I B ,the survival time can＇t be prolonged through platinum-based chemotherapy. Tumor size, T stage, N stage, chemotherapy are independent prognostic factors.

关 键 词：肺肿瘤 预后 抗肿瘤联合化疗方案 生存分析 

分 类 号：R734.2[医药卫生—肿瘤]