CDX2和COX-2与Wnt信号转导途径的关系  

The Relation between CDX2,COX-2 and Wnt Signaling Pathway

作　　者：方三高[1] 肖华亮[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所病理科,重庆400042

出　　处：《医学综述》2012年第6期837-839,共3页Medical Recapitulate

摘　　要：Wnt信号转导途径在细胞发育和肿瘤发生过程中起着重要作用。在此途径中果蝇尾端相关同源异型框转录因子2(CDX2)被认为是一个肿瘤抑制因子,它通过抑制β连环素/T细胞转录因子翻译活性来调节信号的正常转导,从而降低细胞增殖和分化。研究表明CDX2和环氧合酶2(COX-2)可以通过Wnt信号转导途径参与某些生物学效应的调控,两者之间可能存在某种拮抗关系。作为热门研究的肿瘤相关因子,CDX2和COX-2将为癌症的诊断和治疗提供新的有效手段。The Wnt signaling pathway plays important roles in regulating cell development and oncogenesis.As one of the Wnt pathway components,caudal-related homeobox transcription factor 2（CDX2）was identified as a tumor-suppressor.In addition it regulates signaling processes of the normal cells through inhibiting upon thanslation activities of β-catenin/T cell factor,attenuating cell proliferation and differentiation.Studies indicate that CDX2 and cyclooxygenase-2（COX-2） participate in the regulation of the biological effects of the cell,and there might be an antagonistical relationship between CDX2 and COX-2.As the hot research points,it is hoped that they will provide new effective means for diagnosis and therapy of cancer.

关 键 词：信号转导 WNT 同源异型框转录因子2 环氧合酶2 肿瘤发生 

分 类 号：R735.3[医药卫生—肿瘤]