两种不同训练时程方法对海马损伤大鼠水迷宫成绩的影响  

Influences of two different training paradigms on spatial learning and memory performance of hippocampal injured rats

作　　者：边慧[1] 方松[1,2] 缪应达[3] 余化霖[1] 

机构地区：[1]昆明医学院,云南昆明650032 [2]南昌大学第一附属医院医务科,江西南昌330006 [3]中国人民银行昆明市中心支行,云南昆明650223

出　　处：《Zoological Research》2012年第2期237-240,共4页动物学研究（英文）

基　　金："973"计划 (2007CB947703)

摘　　要：为探讨训练时程对大鼠水迷宫成绩的影响,采用直流电解法建立双侧背侧海马损伤大鼠模型,并通过5d(5dtraining)和7d训练(7dtraining)两种不同时程法检测海马损伤大鼠的空间学习记忆能力。结果表明,两种训练法均反映大鼠空间学习能力减退,而在检测空间记忆障碍时则略有不同。与5d训练法相比,7d训练法不仅显示大鼠穿台次数下降,且其在目标象限中的停留时间百分比亦下降。In this study, the 5 d and 7 d training paradigms were adopted to investigate the influences of different training procedures on the performance of spatial learning and memory of the hippocampal injured rats. The results showed that during the hidden-platform acquisition training, similar spatial learning dysfunctions were indicated in those two training paradigms. Whereas, when the spatial memories have been evaluated, compared with the 5 d training groups, the rats under 7 d training procedure not only crossed the platform location less, but also preferred to spend less time in the target quadrant.

关 键 词：水迷宫 空间学习记忆 海马损伤 

分 类 号：R363[医药卫生—病理学]