p63、Bcl-2和PCNA蛋白在B细胞非霍奇金淋巴瘤中的表达及意义  

Expression and significance of p63,Bcl-2 and PCNA protein in B-cell non-Hodgkin′s lymphoma

作　　者：张玉娜[1] 高玉彤[1] 杨晶[1] 

机构地区：[1]天津医科大学病理教研室,天津300070

出　　处：《山东医药》2012年第11期25-27,共3页Shandong Medical Journal

基　　金：天津市高等学校科技发展基金资助项目(20050110)

摘　　要：目的探讨p63、Bcl-2和增殖细胞核抗原(PCNA)蛋白在B细胞非霍奇金淋巴瘤(B-NHL)发生、发展中的作用。方法应用免疫组化染色法检测p63、Bcl-2及PCNA蛋白在50份B-NHL组织和20份反应性增生淋巴组织中的表达,分析各指标间及与B-NHL临床病理参数的关系。结果 p63、Bcl-2和PCNA蛋白在B-NHL组织中阳性表达率分别为60%、78%和80%,在反应性增生淋巴组织中的阳性表达率分别为5%、35%和35%,两两比较P均<0.05;p63与Bcl-2、PCNA蛋白表达均呈正相关,r=0.453、0.800(P<0.001或0.01);三指标与患者年龄、B-NHL病理类型等临床病理参数均无明显关系(P均>0.05)。结论 p63可能与Bcl-2、PCNA协同参与B-NHL的发生,具体机制尚需进一步研究。Objective To investigate the role of p63,Bcl-2 and proliferating cell nuclear antigen（PCNA） Protein in the pathogenesis of B cell non-Hodgkin′s lymphoma（B-NHL）.Methods Immunohistochemistry was used to detect the expression of p63,Bcl-2 and PCNA Protein in 50 cases of B-NHL and 20 cases of reactive hyperplasistic lymphoid tissue,the relationship between the three indexes and clinicopathologic features was analyzed.Results In B-NHL,The positive rate of p63,Bcl-2 and PCNA was 60%,78% and 80% respectively,and in the reactive hyperplastic lymphoid tissue,the positive rate was 5%,35% and 35% respectively,the different expression of p63,Bcl-2 and PCNA between B-NHL and hyperplastic lymphoid tissue were statistically significant（All P0.05）;the expression of p63 was positively correlated with the expression of Bcl-2 and PCNA in B-NHL,r=0.453,0.800（P 0.001 or 0.01）;no significant relationgship between the three indexes and clinicopathologic features of B-NHL（P0.05）.Conclusion The role of p63 is thought to be combined Bcl-2 and PCNA together to lead to the occurrence of B-NHL,the specific mechanism needs further study.

关 键 词：淋巴瘤 非霍奇金 B细胞 P63蛋白 B细胞淋巴瘤/白血病-2 增殖细胞核抗原 

分 类 号：R733.4[医药卫生—肿瘤]