银丹心脑通软胶囊联合佐匹克隆治疗老年慢性失眠的临床疗效  

Clinical efficacy of Yindanxinnaotong soft capsules combined with zopiclone in treatment of elderly patients with chronic insomnia

作　　者：王莲[1] 魏玲[1] 刘茜[1] 

机构地区：[1]成都军区昆明总医院地方干部病房,昆明650032

出　　处：《中华神经医学杂志》2012年第4期405-409,共5页Chinese Journal of Neuromedicine

摘　　要：目的观察银丹心脑通软胶囊和佐匹克隆联用治疗老年慢性失眠的临床疗效，以期为老年慢性失眠的临床治疗提供一种安全有效的措施。方法将成都军区昆明总医院自2010年1月至2011年8月收治的92例老年慢性失眠患者按随机数字表法分为银丹心脑通软胶囊组（30例）、佐匹克隆组（31例）和联合治疗组（31例），并给予相应处理，疗程共持续4周。分别在治疗前、治疗后2周、治疗后4周时采用匹兹堡睡眠质量指数（PSQI）、多导睡眠图检查对患者的睡眠质量进行评价。结果治疗2周后3组PSQI均较治疗前有改善，特别是治疗4周后3组PSQI均较治疗前有明显改善，其中联合治疗组PSQI明显优于佐匹克隆组和银丹心脑通软胶囊组，比较差异均有统计学意义（P〈0．05）。治疗2周后3组患者中有NREM睡眠期S3期、S4期的例数明显上升．尤其是在治疗4周后，3组患者中有NREM睡眠期S3期、S4期的例数更进一步上升，其中联合治疗组治疗效果最好，大部分患者基本能恢复睡眠连续性。治疗4周后3组治疗措施均能使患者的总睡眠时间较治疗前明显延长，且REM睡眠期、NREM睡眠期S3期、S4期（慢波睡眠期）所占比例也较治疗前明显提高，NREM睡眠期S1期、S2期（浅睡眠期）所占比例较治疗前明显缩短，差异均有统计学意义（P〈0．05），其中联合治疗组的总睡眠时间、REM睡眠期、NREM睡眠期S3期、S4期较佐匹克隆组和银丹心脑通软胶囊组明显升高，NREM睡眠期S1期、S2期所占比例明显降低。另外，银丹心脑通软胶囊单独使用同样可以改善患者睡眠质量，只是起效较慢。结论银丹心脑通软胶囊和佐匹克隆联用是一种可供选择的较好的治疗老年慢性失眠的方案。Objective To observe the therapeutic effect of Yindarlxinnaotong soft capsules combined with zopiclone on elderly patients with chronic insomnia. Methods Ninety-two elderly patients with chronic insomnia, admitted to our hospital from January 2010 to August 2011, were randomly assigned into Yindanxinnaotong soft capsule treatment group （n=30）, zopiclone treatment group （n=31） and combined treatment group （n=31）; these patients received treatment for 4 weeks. With pre-treatment and post-treatment self-control statistical method, Pittsburgh sleep quality index （PSQI） was used to evaluate the sleep quality, and polysomnogram was used to detect the changes in sleep architecture. Results All of 3 treatment groups enjoyed considerably improved PSQI, scores especially after 4 weeks of treatment; the improvement in the combined treatment group was significantly more obvious than that in the Yindanxinnaotong soft capsule treatment group and zopiclone treatment group （P〈0.05）; the number of patients enjoyed S3 and S4 during relatively non-rapid eye movement sleep （REM sleep） was obviously increased 2 weeks after treatment; the number was further increased 4 weeks after treatment with combined treatment group enjoying the best results; most of the patients could recover the sleep continuity. All of 3 treatments considerably prolonged total sleep time, slow wave sleep （S3＋S4） time and relatively rapid eye movement sleep （REM sleep） time, which markedly repaired the disruption in sleep architecture and improved sleep quality. The sleep quality of the elderly trom combined treatment group could be more effectively and rapidly improved as compared with that of the other 2 groups; Yindanxinnaotong soft capsules used alone could receive the same result, but it need a longer time. Conclusion The combination of Yindanxinnaotong soft capsules and zopiclone could be an alternative method in the treatment of patients with chronic insomnia.

关 键 词：银丹心脑通软胶囊 佐匹克隆 失眠 联合用药 老年人 

分 类 号：R740[医药卫生—神经病学与精神病学]