急性脑缺血大鼠血浆内皮素1动态变化及尼莫地平治疗的实验研究  

Experimental Investigation in the level of plasma endothelin-1 in rat with acute cerebral ischemia and the treatment of Nimodipine

作　　者：魏东宁[1] 罗毅[2] 

机构地区：[1]北京解放军第309医院神经内科,100091 [2]解放军总医院神经内科

出　　处：《中国急救医学》2000年第2期69-70,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　研究血浆内皮素１（ＥＴ－１） 在急性脑缺血大鼠中的作用，评价尼莫地平地ＥＴ－ １ 的拮抗作用。方法　应用大脑中动脉阻断法（ＭＣＡｏ） 制备急性脑缺血（ＡＣＩ） 大鼠模型。利用放射免疫分析法（ＲＩＡ） 测定ＡＣＩ大鼠急性期血浆ＥＴ－ １含量以及尼莫地平治疗后ＥＴ－ １ 的变化。结果　手术组急性期血浆ＥＴ－１ 含量与对照组比较差别显著（ Ｐ＜ ０－０５）。手术组与治疗组血浆ＥＴ－ １ 含量比较差别不显著。结论　急性脑梗死大鼠急性期血浆ＥＴ－１ 水平增高对大鼠脑缺血会产生不利的影响，尼莫地平仅有部分拮抗ＥＴ－ １Objective To study the dynamical change of plasma ET-1 in the rats with acute cerebral ischemia and the treatment efficacy of Nimodipine.Methods Middle cerebral artery occlusion (MCAo) in rats produces an model of acute cerebral ischemia (ACI).The level of plasma ET-1 in rats with ACI were assayed by radioimmunoassay (RIA).Results In acute stage,the levels of plasma ET-1 were significantly increased ( P <0 05) as compared with controls.The levels of plasma ET-1 of the oprative group were not siginificantly increased as compared with the group of treatment.Conclusions The increase of plasma ET-1 of ACI of rats in actue stage may produce harmful influence to the cerebral ischemia of rats.Nimodipine can resist ET-1 partly,but it is not a effective drug. [

关 键 词：脑缺血 内皮素1 尼莫地平 大鼠 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R972.4[医药卫生—临床医学]